The antithrombotic effects of three thrombin inhibitors (hirudin, NAPAP and argidipine) were investigated in an experimental thrombosis model using laser lesions of rat mesenteric venules. Furthermore, their in vitro anticoagulant activity (partial thromboplastin time, thrombin time, Heptest, inhibition of factor Xa and factor Xa) in human platelet poor plasma (PPP) and their in vitro and ex vivo activities were studied in rat plasma. All three thrombin inhibitors showed significant and dose-dependent antithrombotic effects after intravenous injection, if venules were damaged, which lasted for more than 4 but less than 8 h. The anticoagulant effect observed in vitro did not differ much between human and rat PPP. The two synthetic thrombin inhibitors NAPAP and argidipine were about as effective as hirudin in vitro; however, the ex vivo effect after intravenous injection of hirudin in rats was more pronounced than that observed with the two synthetic thrombin inhibitors. The antithrombotic effect of all three thrombin inhibitors in the laser model lasted much longer than the anticoagulant activity. This fact needs further investigations in the future.

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C. Harries und W i l h e l m Haarmann: Ueber die Einwirkung von Hydroxylamin auf ungesattigte Saureester.3orgetr. von C. Harrieaind. Sitzungamll.Jan.1901;eingeg.:~m1:1.Jan.1!~04.)Vor ca. 3 Jahren l) haben wir der Gesellschaft iiber Versuche berichtet, die darauf hinzielten, die Resultate, welche sich bei dem Studium der Einwirkung von Hydroxylamin auf ungesiittigte Ketone crgeben hatten, zu verallgemeinern, also festzustellen, ob auch andere Systerne ron Doppelbindungen als diejenigen der Ketone zur Addition ron Hydroxylamin befahigt seien. Wir haben einige Beispielr nu8 1) Vergl. Diss. von W. H a a r m a n n , Berlin 16. Mgrz 1901.

Summary. About 5 % of tumors of the stomach are neither carcinomas nor sarcomas. A neurinoma occurs in about 1% of the cases with rare benign and semimalignant tumors. Diseases other than epithelial or systemic disease can be observed in about 3 % of the cases, as for example Hodgkin disease and non-Hodgkin lymphoma. Two of our own cases with non-Hodgkin lymphoma located primarily in the stomach (cardia, gastric stump) are presented. One percent of gastric tumors are regarded as precancerosis, such as Menetrier disease and polyposis. The findings are illustrated and discussed on the basis of our own cases.Key words: Gastric tumors -Hodgkin disease -Non-Hodgkin lymphoma.Zusammenfassung. In ca. 5 % der Magentumoren handelt es sich nicht um Carcinome oder Sarkome. So finden sich in 1% der F~ille seltene benigne und semimaligne Tumoren, wie das Neurinom, welches beispielhaft dargestellt wird. In 3 % finden sich nicht epitheliale Malignome und Systemerkrankungen mit Befall des Magens wie z. B. der Morbus Hodgkin und die Non-Hodgkin-Lymphome. Aus dem eigenen Krankengut werden 2 F~ille yon Non-Hodgkin-Lymphomen mit prim/irem Befall des Magens an der Kardia und im Magenstumpf dargestellt. In 1% der Magentumoren handelt es sich um Praecancerosen wie den Morbus Menetrier und die Magenpolyposis, die ebenfalls an 2 Beispielen kasuistisch dargestellt werden. Sehliisseiwiirter: Magentumoren -Morbus Hodgkin -Non-Hodgkin-Lymphom.

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