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Patients with asthma have an ongoing inflammation, which can be assessed by measuring serum C-reactive protein.Objective: To explore whether CRP could be used as a predictor of disease outcome in asthma. Methods: A Cross-sectional study was conducted among 50 asthma patients attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSphera TM CRP Latex Slide test kit was used to estimate serum C-reactive protein. Results and Observation:The present study was conducted on fifty asthma patients in which serum CRP level showed association with severity of asthma ( p=0.001) but serum CRP level with spirometric parameters showed significant negative correlation; FVC (r=-0.711, p<0.001), FEV 1 (r=-0.665, p<0.001), FEV 1 /FVC (r=-0.429, p=0.002), FEF 25-75% (r=-0.535, p<0.001), and PEFR (r=-0.515, p<0.001). Conclusion:In our study we found association between serum CRP level and asthma and plasma CRP may be used as a marker of prognosis in patients with asthma.

Abstract Patients with the chronic obstructive pulmonary disease have ongoing systemic inflammation, which can be assessed by measuring serum  C- reactive protein. Objective: To explore whether CRP could be used as an independent predictor of disease outcome in COPD. Methods: A cross-sectional study was conducted among 50 COPD patients attending Respiratory Medicine outpatient services in the Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum c-reactive protein. Results and observation: The present study was conducted on fifty COPD patients in which serum CRP level showed positive correlation with COPD (p=0.002) but serum CRP level with spirometric parameters showed significant negative correlation;FEV1 (r=-0.451, p=0.001), FEV1/FVC (r=-0.617, p<0.001) and PEFR (r=-0.398, p=0.004). Conclusion: In our study, we found an association between serum CRP level and severity of COPD and Plasma CRP may be used as a marker of prognosis in COPD as the small increase is associated with poorer prognosis in COPD. Keywords: CRP; Chronic obstructive pulmonary disease (COPD); Imphal.