Aims:To evaluate intentional replantation based on clinical and radiographic assessment criteria over a two year period. Materials and Methods: The clinical trial was conducted at the

Objectives This study aimed to assess the repair of bone defects with or without grafts using biphasic synthetic micro-granular hyaluronic acid (HA) with β-TCP and bovine type I collagen (Osteon II Collagen) with or without either hyaluronic acid or a collagen membrane in surgically created bone defects in the tibia of rabbits. Methods Fifteen male rabbits were divided into 3 groups, each with 5 rabbits. Two bone defects were made in each tibia. In the right tibia, the defects were either filled with clot as a control or grafted with Osteon II Collagen and hyaluronic acid. In the left tibia, the other two defects were filled with Osteon II Collagen alone or with Osteon II Collagen and a collagen membrane. The specimens were observed one, two, and four weeks after surgery. Histological examinations were used to evaluate the degree of healing according to the amount of newly formed bone. Results The combination of the bone grafting biomaterial with hyaluronic acid was found to develop into the most advanced stages of the bone repair process at the second and fourth week only ( p ≤ 0.05), compared to the biomaterial with a collagen membrane, as well as the other groups. On the other hand, the biomaterial in combination with a collagen membrane showed significantly more bone formation than the biomaterial alone or the control group by the fourth week. Conclusions The local application of hyaluronic acid and collagen membranes made a greater contribution to the bone repair process in the tibia of rabbits than the bone graft substitute (Osteon II Collagen) alone.

Objectives The present study aims to evaluate the healing effect of a new topical paste formulation on mucosal wounds. Methods This study was conducted in 40 adult male rabbits. The animals were divided into two groups: a control group containing rabbits that were treated with only Orabase paste (comprising olive oil and beeswax) and an experimental group that included rabbits that were treated with Orabase paste containing hyaluronic acid, rosemary extract, and metronidazole. Each of these groups was randomly divided into four groups according to the observational period (post-treatment days 1, 3, 7, and 15). Further, biopsy samples for histological examination were obtained from the animals’ oral mucosal defects. Results We found that the new formulation (Orabase paste containing hyaluronic acid, rosemary extract, and metronidazole) had a stronger healing effect. The inflammation and re-epithelization scores at 3–7 days for the experimental group appeared superior in which ( P -values were 0.038 and 0.034 for inflammation and 0.046 and 0.025 for re-epithelization) respectively. Furthermore, the re-epithelization score on the 15th day for the new formulation was significant ( P ≤ 0.05), with the inflammatory response being milder. Conclusions Topical application of new paste formulation provided good therapeutic results. The new formulation was effective in resolving inflammation during specific phases of mucosal healing and significantly advanced wound healing at different stages. It also afforded a better healing response in terms of reduced wound contraction.