The efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers

Abid, Wafaa K.; Naser, Alyaa I.

doi:10.1016/j.jtumed.2021.05.005

Cited by 3 publications

(2 citation statements)

References 28 publications

(27 reference statements)

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“…In this context, a pH/glucose dual-responsive metformin release hydrogel dressing with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot wound healing has been recently described by Liang et al [49]. In a different study, the efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers was presented [50]. In the study, conducted using 40 adult male rabbits, the new formulation was effective in resolving inflammation during specific phases of mucosal healing and improved the wound healing process at different stages.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

et al. 2022

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Impaired diabetic wound healing is a major concern for health care professionals worldwide, imposing an intense financial burden and reducing the quality of life of patients. A dysregulation of this process can be responsible for the development of intractable ulcers and the formation of excessive scars. Therefore, the identification of novel pharmacological strategies able to promote wound healing and restore the mechanical integrity of injured tissue becomes essential. In the present study, fluoxetine ecofriendly nanoemulsion (FLX-EFNE) was prepared and its potential efficacy in enhancing wound healing was tested in diabetic rats. The Box–Behnken response surface design was used to select the optimized formulation that was prepared by the high-shear homogenization-based technique. A Zetasizer was used for the characterization of the optimized formulation, providing a FLX-EFNE with a globule size of 199 nm. For the in vivo study, a wound was induced by surgical methods, and diabetic rats (streptozotocin-induced) were divided into five groups: untreated control, vehicle-treated, FLX, FLX-EFNE, and positive control receiving a commercially available formula. The treatment continued from the day of wound induction to day 21. Then, the animals were sacrificed and skin tissues were collected at the site of wounding and used for biochemical, histopathological, immunohistochemical, and mRNA expression assessments. In the FLX-EFNE treated group, the rate of wound contraction and signs of healing were significantly higher compared to all other groups. In addition, angiogenesis, proliferation, and collagen deposition were enhanced, while oxidative stress and inflammation decreased. The present data highlight the enhanced wound healing activity of the optimized FLX-EFNE formulation.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

et al. 2022

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“…Potential healing of rosemary essential oil was highlighted in the study of Abu-Al-Basal et al [ 57 ], where Rosmarinus officinalis essential oil reduced inflammation and wound debridement when topically applied on wounds. The study of Abid et al [ 87 ] also showed an obvious synergistic effect of hyaluronic acid, rosemary oil, and metronidazole to achieve better wound healing.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Mekkaoui

Assaggaf

Qasem

et al. 2021

Foods

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Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.

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Effect of Montelukast on Healing of Induced Oral Ulcer in Rats

Majeed¹,

Mammdoh²,

Al-Allaf³

2023

MMSL

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Background: Oral ulcers are among the common recurrent oral diseases which seek medical help; the underlying pathology is yet obscure, making medical intervention difficult. Aims: The purpose of this study was to investigate if montelukast could help mouth ulcer model in Albino rats. Methods: The rats were divided into two groups of 24, the control group of 12 rats with induced ulcer and no therapy, and the treatment group with induced ulcer and treated orally with Montelukast 20 mg/kg. Each group had six rats sacrificed after 3 and 7 days of treatment. The lingual ulcer was produced with cotton soaked in 70% acetic acid solution and rubbed against the tongue for 2 minutes. Discolouration of tongue tissue has been noticed. Animals in all groups were weighed on days 1, 3, and 7 following mucosal ulcerations were confirmed. Results: On days 1, 3, and 7, the body weight of the treatment group rats improved as compared to the control group. On days 3 and 7, the tongue histological section of the control group revealed a wide gap of the site of ulcer in the lingual mucosa, inflammatory exudate, and severe infiltration of inflammatory cells (score 3) without re-epithelialization (score 0). Lingual sections of MTK treated group after ulcer induction on day 3 showed the same lesions as the control group whereas after 7 days demonstrated improvement in inflammatory indicators as inflammatory exudate and infiltration of inflammatory cells (score 1), formation of granulation tissue composed of fibrous tissue and angiogenesis and Re-epithelialization (score 1) comparing with the control group. Conclusion:The present study found Montelukast's anti-inflammatory potential characteristics to treat generated lingual ulcers in rats.

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The efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers

Cited by 3 publications

References 28 publications

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

RETRACTED: Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Effect of Montelukast on Healing of Induced Oral Ulcer in Rats

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