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Cancer is the second reason of deaths worldwide while breast cancer is the more spread cancer in women, comprising 29 % from all cancers that they are affected Samples were obtained from patients undergoing surgery in center from breast cancer in oncology teaching hospital Al-Eluia hospital for woman care All blood samples were taken of the patients (110 women) and divided into four groups benign, malignant, radiotherapy and control group In order to measurement estrogen levels which are influenced by the menstrual cycle, the main groups were furthermore divided into subgroups , premenopausal and postmenopausal women The mean value ± SE of Body Mass Index (BMI) for control, benign, malignant and radiotherapy breast cancer were showed a non-significant change in the comparison of groups according to the Duncan test Estrogen were increased before therapy but decreased following therapy The levels of malondialdehyde (MDA)were elevated in patients after radiotherapy The mean value ± SE of vitamin E were decreased in studied groups Present study aims to study the effects of serum estrogen, vitamin E and antioxidant status in breast cancer patients.

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Megalin is a large multifunctional endocytic clearance receptor for circulating proteins that has been implicated in vitamin D uptake and delivery to the kidney for activation to 1,25(OH) 2 D .Knockout of the megalin gene in mice usually is lethal but the few survivors were characterized as having severe rickets. The findings suggested that VDBP may be a ligand for megalin. The model proposes that VDBP, carrying vitamin D, is filtered by the glomerulus and reabsorbed by the "cargo" receptor megalin or the megalin/cubilin complex in tubular cells, thereby preventing urinary loss of vitamin D. In addit ion to the classical hypothesis of free vitamin D uptake by diffusion in the proximal convoluted tubules at the basolateral site of the epithelium. The aim of this study was evaluate serum levels of megalin and cubilin in relation with vitamin D . This study included Eighty-four participants of both gender (28 are control and 56 T2DM patients).estimation of serum levels of cubilin and megalin was done using commercial ELISA kit of BT/ China, as well as VD3 measurement.Using of HOMA -IR, DM2 patients were sub divided to insulin resistance (IR) and insulin sensitive (IS) groups.There was significant difference between C and IS patient group (0.222± 0.206), (1.222±0.403) , p-value (0.000) respectively . While there was significant difference between C and IR patient group (0.222± 0.206) , (3.688±1.238) ,p-value (0.000), also there was significant difference between IS and IR patient group (1.222±0.403), (3.688±1.238) , p-value (0.000) respectively. In conclusion, experimental studies and findings in rare disorders of receptor dysfunction have established the important role of megalin and cubilin in association with vitamin D.