A reactive composite of LiBH4–xLa2Mg17 was successfully prepared by means of mechanochemical reaction under 40 bar of H2. It was found that MgH2 and LaH3 were readily formed in situ during high-pressure ball milling, and a strong dependency of hydrogen storage performance of the LiBH4–xLa2Mg17 composites on the content of La2Mg17 was observed. The as-prepared LiBH4–0.083La2Mg17 composite under 40 bar of H2 exhibits superior hydrogen storage properties as ∼6.8 wt % of hydrogen can be reversibly desorbed and absorbed below 400 °C. It was also purposed that the self-decomposition of MgH2 first occurred to convert into Mg with hydrogen release upon dehydrogenation and subsequently catalyzed the reaction of LiBH4 and LaH3 to liberate additional hydrogen along with the formation of LaB6 and LiH. The in situ formed MgH2 and LaH3 provide a synergetic thermodynamic and kinetic destabilization on the de/hydrogenation of LiBH4, which is responsible for the distinct reduction in the operating temperatures of the as-prepared LiBH4–xLa2Mg17 composites.
As a research topic integrating various subjects and technologies, Metaverse research has been a global concern in recent years. This study explores the hotspots and frontiers of academic research on the Metaverse based on a bibliometric analysis from 2012 to 2021. A keyword retrieval dataset related to Metaverse research was constructed based on expert consultation and manual reading of the literature, retrieving articles and conference papers from the Scopus database. Critical points in Metaverse research are represented in terms of research scale, keyword co-occurrence networks, keyword citation bursts, and international collaborative networks with the application of VOSviewer and CiteSpace’s bibliometric visualization software. The results indicate that Metaverse research is experiencing rapid growth, with countries/regions increasing their production at varying speeds. The results also indicate the three most prolific countries, the United States, China and Germany, for comparison, showing the leading topic as virtual reality in Metaverse research, and we find that there are differences in topic clustering and hotspot evolution among the three countries over the past decade. By determining the current research status and the overall development path of the Metaverse field, the paper intends to provide a reference for the future research development and technical application of the Metaverse.
Despite the superior tumor lytic efficacy of oncolytic viruses (OVs), their systemic delivery still faces the challenges of limited circulating periods, poor tumor tropism, and spontaneous antiviral immune responses. Herein, a virus‐concealed tumor‐targeting strategy enabling OVs‘ delivery toward lung metastasis via systemic administration is described. The OVs can actively infect, be internalized, and cloak into tumor cells. Then the tumor cells are subsequently treated with liquid‐nitrogen‐shocking to eliminate the pathogenicity. Such a Trojan Horse‐like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor‐targeted delivery for more than 110‐fold virus enrichment in the tumor metastasis. In addition, this strategy can serve as a tumor vaccine and initiate endogenous adaptive antitumor effects through increasing the memory T cells and modulating the tumor immune microenvironment, including reducing the M2 macrophage, downregulating Treg cells, and priming T cells.
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