Este estudo teve como objetivo comparar as respostas cardiovasculares e de óxido nítrico (NO) à contração isométrica voluntária máxima (CIVM) com diferentes grupos musculares (leg press [LEP] e preensão manual isométrica [IHG]) de adolescentes com e sem síndrome de Down (SD). Alem de comparar a força IHG absoluta e relativa entre os grupos. Onze adolescentes com SD (14,1 ± 1,0 anos) e dez sem SD (13,7 ± 1,25 anos) realizaram duas sessões experimentais de exercícios LEP e IHG: 1) sessão de familiarização e 2) 3 tentativas x 5 segundos de contração na CIVM com 3- intervalo mínimo de descanso. A pressão arterial (PA), a frequência cardíaca (FC) e o NO foram coletados em repouso, imediatamente após a sessão de exercício e 10 minutos após o exercício. A dosagem de NO na saliva foi realizada pelo método colorimétrico de Griess. Não houve diferenças para respostas cardiovasculares e NO entre os grupos para CIVM. No entanto, o SD teve uma resposta cardiovascular menor, mas não significativamente, em repouso e após os testes de CIVM do que aqueles sem SD. O grupo SD apresentou maior concentração de NO em repouso, recuperação e após IHG quando comparado ao grupo não SD (P <0,05). Além disso, adolescentes com SD apresentaram menor nível de força de IHG absoluta e relativa quando comparados àqueles sem SD (P = 0,001). Indivíduos com SD apresentam menor resposta cardiovascular em repouso e após testes de CIVM e maior resposta de NO após o exercício quando comparados ao grupo sem SD.

Objective: To describe the profile of blood donors in a hospital in the Midwest of Brazil with its own blood bank to have a diagnostic view of the establishment and enable the planning of improvements in services. Methods: This is a descriptive, retrospective study with a quantitative approach. A proportional stratified sampling technique was used, with a confidence level of 95% and a margin of error of 5%, to represent and characterize the study population, obtaining a sample of 363 donors. Subsequently, a proportional allocation was performed in the established groups (fit donors, unfit donors, and platelet apheresis donors). Results: The profile of eligible donors in the institution studied was composed of married (55.2%), male (63.7%), aged between 20 and 30 years (40.4%), with O RhD+ blood (46.7%) and A RhD+ (29.6%) more prevalent. Apheresis platelet donors (50%) are single, female (81.3%), and aged between 31 and 40 years (43.8%). As for unfit donors, 94.8% are temporary-unfit donors, married donors (53.2%), female (54.5%), and between 20 and 40 years old (54.6%), with the categories of health condition and lifestyle being the most prevalent reasons for disability. Conclusion: There is a hegemony for replacement and first-time donors, showing the effectiveness of the solidarity policy implemented in the institution, but it shows the low effectiveness in the loyalty of these donors.

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Background This study was designed to compare the cardiovascular and nitric oxide (NO) responses to maximal voluntary isometric contraction (MVIC) with different muscle groups (leg press [LEP] and isometric handgrip [IHG] exercise) of adolescents with Down syndrome (DS) and age-matched non-DS peers. We also aimed to compare the absolute and relative IHG strength between groups. MethodsEleven adolescents with DS (14.1 ± 1.0 years) and ten without DS (13.7 ± 1.25 years)participants performed two experimental sessions of LEP and IHG exercises: 1) familiarization session and 2) 3 attempts x 5-sec contraction at MVIC with 3-min rest interval. Blood pressure (BP), heart rate (HR) and NO were collected at rest, immediately post-exercise session, and 10-min post-exercise. Results There were no differences for cardiovascular and NO responses between groups for MVIC test using different muscle groups. However, DS group displayed a lower but not significantly cardiovascular response at rest and after MVIC tests than controls. Furthermore, DS group displayed a higher NO- concentration at rest, recovery and after IHG when compared to controls (P< 0.05). In addition, DS adolescents displayed a significantly lower level in absolute and relative IHG strength when compared to controls (P = 0.001). Conclusions Individuals with DS display a lower cardiovascular response at rest and after MVIC tests than controls and higher NO response after exercise.