Asian Pac J Cancer Prev, 16 (2), 513-517 IntroductionLung cancer is the leading cause of death of cancer world-wide, causing more than 1 million deaths per year (Jemal et al., 2010). It is a disease characterized by uncontrolled cell growth in tissues of the lung. The global cancer burden in annual cases is projected to double by 2050, and lung cancer is expected to remain the leading cause of all cancer deaths during that time (Brothers et al., 2013). Cigarette smoking remains the main risk factor for lung cancer, with 85%-90% percent of lung cancer cases caused by active or passive smoking. Conventional treatments for lung cancer are surgery, radiotherapy and chemotherapy. And the choice of method depends on the type, progress and relevant genes of lung cancer. Besides, targeted therapy, as a more accurate and specific treatment, has come into our field of vision for us to choose from. It won't cause any harm to adjacent normal lung cells when it uses specific drugs to identify and target cancer cells.Recently, genetic, transcriptomic and epigenomic biomarkers are emerging as tools for the early diagnosis of lung cancer both in the screening setting and diagnostic. Furthermore, epigenetics refers to heritable modifications

We used cross‐sectional and longitudinal studies to comprehensively compare hepatic steatosis measurements obtained with magnetic resonance imaging–proton density fat fraction (MRI‐PDFF) and controlled attenuated parameter (CAP) in hepatic steatosis in adults with nonalcoholic fatty liver disease (NAFLD). A total of 185 participants with NAFLD and 12 non‐NAFLD controls were recruited. CAP and MRI‐PDFF data were collected at baseline from all participants and from 95 patients included in the longitudinal study after 24 weeks of drug or placebo intervention. Pearson correlation, linear regression, and piecewise linear regression analyses were used to evaluate the relationship between the two modalities. Linear analysis suggested a positive correlation between CAP and MRI‐PDFF (r = 0.577, p < 0.0001); however, piecewise linear regression showed no correlation when CAP was ≥331 dB/m (p = 0.535). In the longitudinal study, both the absolute and relative change measurements were correlated between the two modalities; however, the correlation was stronger for the relative change (relative r = 0.598, absolute r = 0.492; p < 0.0001). Piecewise linear regression analysis revealed no correlation when CAP was reduced by more than 53 dB/m (p = 0.193). Conclusions: We found a correlation between CAP and MRI‐PDFF measurements for grading hepatic steatosis when CAP was <331 dB/m. While the measured absolute change and relative change were correlated, it was stronger for the relative change. These findings have implications for the clinical utility of CAP or MRI‐PDFF in the clinical diagnosis and assessment of NAFLD.

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