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The effectiveness of chitosan as an intraoperative topical hemostatic agent for brain tissue was tested. Cerebral cortical lesions were made in 10 cats. Chitosan was used to obtain hemostasis. The elapsed time from the application of the hemostatic agent to hemostasis was determined. The animals were killed and the lesions were examined grossly and microscopically to evaluate the biocompatibility of chitosan. Chitosan was easy to apply and required minimal subsequent manipulation. Histopathological examination revealed that chitosan is biocompatible with cerebral cortex.

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The recent use of generalized body hypothermia as an adjunct to anesthesia has prompted the application of this technique to the management of various types of infections. The isolated case reports on the use of hypothermia in clinical infections have attributed varying degrees of success to the use of this agent, but these studies in general have not been adequately conitrolled, nor has the mechanism of such benefit been properly investigated (1-9).The rationale for the use of chronic hypothermia in the management of infectious processes rests upon the fact that the metabolism of bacteria pathogenic to man is reduced at temperature levels below that of normal body temperature. Reduction of the temperature of the animal might retard bacterial growth with possible benefit to the host. Such benefit would occur only if host resistance is depressed less than is bacterial growth.The effect of cold on the resistance to infection was first noted in 1878 by Pasteur, Joubert, and Chamberland (10), who found that immersion of an unanesthetized fowl in cold water increased the susceptibility of the animal to subsequent anthrax infection. Thereafter numerous studies were carried out on the effect of body chilling ( 11 ) or the local application of cold (12) on host resistance to infection. Other studies have been reported on the in vitro alteration of phagocytosis by reduced temperatures (11,(13)(14)(15)(16)(17)(18).The purpose of this experiment is to determine the effect of prolonged (24-hour) generalized body hypothermia on the course of experimental peritonitis in anesthetized mice. It is emphasized that these animals were subjected to hypothermia after narcosis. This

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