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Removal of the ruptured follicle shortly after ovulation did not alter the response at the 19th hour in the uterus stage. The beginning of the plateau of the response curve approximately coincided with the time at which the oviducal egg became fully plumped, i.c., reached its almost maximum size. The response curve was interpreted as the expression of a change in the mechanical relations between the uterus and the contained egg, rather than a change in intrinsic sensitivity due to the action of the ruptured follicle.

Nine heptaene macrolide antifungal antibiotics, amphotericin B, azacolutin, candicidin, hamycin, heptamycin, levorin, mycoheptin, perimycin, and trichomycin were active against a systemic Candida albicans infection of mice. While all compounds exhibited similar activity when administered subcutaneously, only amphotericin B and mycoheptin showed significant activity when given orally. This high level of oral activity in mice is probably a characteristic of the group of heptaenes that contain only mycosamine as a nitrogenous moiety and thus should extend also to the candidin complex. Although amphotericin B is inactive when given orally to man, mycoheptin, candidin, or a chemically-modified heptaene might show useful therapeutic efficacy when given to manby the oral route.In an earlier report1) we compared the therapeutic activities of two heptaene macrolide antifungal antibiotics, amphotericin B and hamycin, when these were administered by the oral route to mice infected with Candida albicans. Amphotericin B proved to be far more effective than hamycin. We had long known that amphotericin B, in this model infection, was approximately three times more effective when administered subcutaneously than when given orally. In further studies with hamycin, we were surprised to find that this same relationship did not hold with this second antibiotic. We, therefore, decided to study as many members of the heptaene antifungal group as were available to us, in an effort to account for this difference.