To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic function experiment, it was found that CSCM could facilitate platelet adherence, platelet aggregation, and platelet activation in vitro. Besides, the maximum swelling of CSCM submerged in PBS for 50 min was over 300% of that exhibited by commercial hemostatic compound microporous polysaccharide haemostatic powder (CMPHP). In addition, CSCM exhibited good biodegradability and non-cytotoxicity. These results demonstrated that CSCM may be useful in platelet plug formation, and this study would provide important information for further research on hemostasis experiment in vivo.

Nanoparticles (NPs) have demonstrated a potential for hepatocarcinoma therapy. However, the effective and safe NP-mediated drug transportation is still challenging due to premature leakage and inaccurate release of the drug. Herein, we designed a series of core cross-linking galactose-based glycopolymer-drug conjugates (GPDs) NPs with both redox-responsive and pH-sensitive characteristics to target and program drug release. Glycopolymer is comprised of galactose-containing units, which gather on the surface of GPD NPs and exhibit specific recognition to hepatocarcinoma cells, which over-express the asialoglycoprotein receptor. GPD NPs are stable in a normal physiological environment and can rapidly release the drug in hepatocarcinoma cells, which are reductive and acidic, by combining disulfide bond cross-linked core, as well as boronate ester-linked hydrophilic glycopolymer chain and the hydrophobic drug.

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Purpose -The purpose of this paper is to present a new stereolithograhy (SL) process which could substantially improve the efficiency of building process through controlling the beam spot size and optimizing the process parameters dynamically. Design/methodology/approach -In this process, the focus length of UV laser scanning head is changed by the dynamic focus mirror according to the building program. The beam spot in the resin surface varies with the focus length, and the laser power is adjusted accordingly to the changing spot in building process. Findings -The study finds that the efficiency of building process has a close relationship with the beam spot size. The experiments showed that the larger the laser spot diameter was, the less the depth and the larger the width of the cured lines would be. Then the building program would adjust the UV laser power to compensate for the decreased curing depth caused by the enlarged beam spot. At last, the spot compensation was optimized for the new method that could keep the same building accuracy with the traditional SL process. Originality/value -The variable beam spot process could improve the building efficiency by 30 percent without increasing the cost of system, and keep the same accuracy compared with the conventional SL process.

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