Background: Recent research has uncovered tumor suppressive and oncogenic potential of miRNAs. Results: miR-941 expression is regulated by DNA methylation, and is an important regulator of cell proliferation, migration, and invasion by directly targeting KDM6B in hepatocellular carcinoma (HCC). Conclusion: miR-941 may play an important role in suppressing tumor growth and metastasis in HCC. Significance: miR-941 may provide a potential biomarker for the diagnosis and treatment of HCC.

A drug-drug interaction occurs when the effect of one drug is altered by the presence of another drug which is generally associated with the induction of cytochrome P450s (CYPs) activity. Thus, unexpected treatment failures often happen resulting from inappropriate coadministration in fisheries. However, little information is available about CYP induction in fish. The reaction of difloxacin (DIF) biotransformation to sarafloxacin (SAR) belongs to N-demethylation catalyzed mainly by CYP(s). In order to supply useful information on CYP induction, the present study assessed the effects of fish-specific CYP inducers on DIF N-demethylation and enzyme kinetics in kidney cell of Chinese idle (CIK; grass carp (Ctenopharyngodon idellus)) by RP-HPLC. Results demonstrated that the amounts of SAR formation and enzymatic parameters Clint and Vmax were significantly increased due to beta-naphthoflavone (BNF) pretreatment. Therefore, we suggest that CYP1A may be involved in DIF N-demethylation in CIK. This study provides instructive information to ensure treatment success via avoiding CYP induction in fisheries.

In order to solve the sealing problem between the two cavities of the servo actuator in harsh environment, the high pressure resistant hydraulic lock with integrated cone soft seal technology is designed by using nonmetal rolling molding and self-balanced technology of a integrated valve core. Its life and sealing effect were tested; the results showed that this new type hydraulic lock has reliable open and shut characteristic as well as reliable sealing effect. It can ensure the servomechanism is fully close anywhere. The new type design has been applied to certain model of carrier rocket.