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Strategy, Management and Health PolicyPreclinical Research Ilex hainanensis Merr. leaves are widely used for their diuretic, antihypertensive, antilipemic, and anti‐inflammatory properties. The main chemical components in these leaves are flavonoids. To evaluate whether the total extract (TE) from I. hainanensis Merr. may improve hepatic steatosis and further investigate the preventive effects of the total flavonoid extract (TFE) from I. hainanensis Merr. on hepatic steatosis, rats were given either a high‐fat diet alone or the same diet plus the TE or the TFE for 4 weeks. TE and TFE improved liver histology with a reduction in the levels of serum alanine aminotransferase and the serum aspartate aminotransferase as well as a decrease in excess accumulated lipids in the serum and liver. TE and TFE decreased the levels of fasting serum glucose, fasting serum insulin, insulin resistance index, and tumor necrosis factor‐α levels in rats fed a high‐fat diet while improving the insulin sensitivity index. These benefits were associated with an increase in superoxide dismutase activity and a decrease in malondialdehyde in the livers of rats fed a high‐fat diet. In conclusion, TE and TFE exert protective effects against hepatic steatosis in rats that are fed a high‐fat diet, possibly through its ability to regulate lipid metabolism and antioxidants, enhance insulin sensitivity, and improve the release of adipocytokines.

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By constructing a regional innovation capability evaluation index system, comprehensively measuring the innovation capabilities of cities in the Yangtze River Delta region, and using the modified gravity model to construct the basic spatial radiation framework for innovation in the Yangtze River Delta region, it is important for Shanghai Science and Technology Innovation Center and 26 core cities in the Yangtze River Delta region. The innovative radiation intensity was measured and analyzed, and further visualized analysis was made with the help of ArcGIS10.5 software. The results show that Shanghai Science and Technology Innovation Center is at the core of the innovation spatial structure of the Yangtze River Delta, but the scope of innovation radiation is relatively small; the spatial distribution of urban innovation in the Yangtze River Delta region is obviously unbalanced; the innovation environment is in the development of urban innovation. The role is increasingly obvious. Based on this, a number of suggestions for the Shanghai Science and Technology Innovation Center to lead the realization of the coordinated development of innovation in the Yangtze River Delta are put forward.