Cancer has been one of the most common life‐threatening diseases for a long time. Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) have limited effects due to drug resistance, unsatisfactory treatment efficiency, and side effects. In recent years, photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) have been utilized for cancer treatment owing to their high selectivity, minor resistance, and minimal toxicity. Accumulating evidence has demonstrated that selective delivery of drugs to specific subcellular organelles can significantly enhance the efficiency of cancer therapy. Mitochondria‐targeting therapeutic strategies are promising for cancer therapy, which is attributed to the essential role of mitochondria in the regulation of cancer cell apoptosis, metabolism, and more vulnerable to hyperthermia and oxidative damage. Herein, the rational design, functionalization, and applications of diverse mitochondria‐targeting units, involving organic phosphine/sulfur salts, quaternary ammonium (QA) salts, peptides, transition‐metal complexes, guanidinium or bisguanidinium, as well as mitochondria‐targeting cancer therapies including PDT, PTT, CDT, and others are summarized. This review aims to furnish researchers with deep insights and hints in the design and applications of novel mitochondria‐targeting agents for cancer therapy.

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A novel plasmonic gold nanocarrier using a modular RNA scaffold significantly improves delivery efficiency into diverse human cells, as presented by Norbert O. Reich and co-workers in article number 1602473. The orthogonal positioning of cell targeting peptides and functional RNA provides unprecedented control in the delivery of biologically active RNA. NIR light-triggered RNA release with spatio-temporal control further enhances the RNA delivery efficiency. Plasmon-Enhanced Spectroscopy Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) is invented to break the long-standing material-and substrate-specific limitations in SERS (surface-enhanced Raman scattering), as presented by Jian-Feng Li and co-workers in article number 1601598. The metal nanoparticle acts as a plasmonic nanoantenna for near field amplification, and the ultra-thin dielectric shell prevents the interference of environmental species. Single Crystals Perovskite single-crystalline microplate arrays are fabricated on a large scale via inkjet printing technology by Mingzhu Li, Yanlin Song, and co-workers in article number 1603217. By modulating the inkjet droplet volume and the ink composition, a tunable single/multiple mode laser with high quality factors up to 863 and three primary-color microplates are achieved. This work makes a great step toward the multifunction of on-chip perovskite crystals, which can boost its promising applications on integrated coherent light sources and other optoelectronic applications. Recent progress in the development of metallofullerene nanomaterials for next-generation biomedical applications is reviewed. For example, the metallo-fullerenes are promising magnetic resonance imaging contrast agents, which are attractive by shielding toxic metals from the bioenviroment. This nanoplatform readily allows specific targeting and multi-modality capability for both diagnostic and therapeutic applications. reviews Shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) has been invented to break the long-standing material-and substrate-specific limitations in conventional SERS. The noble metal nanoparticle acts as plasmonic nanoantenna for the near field amplification , and the ultra-thin and inert dielectric shell prevents the interference of environmental species. This SHINERS concept could be applied to a lager family of surface-enhanced spectroscopies. Catalysts Hydrogen is considered as sustainable and environmentally friendly energy for global energy demands in the future. Here a Co-FeS 2 catalyst with surface phosphide doping (P/Co-FeS 2) for hydrogen evolution reaction (HER) in acidic solutions is developed. The P/Co-FeS 2 exhibits superior HER electrochemical performance with overpotential of-90 mV at 100 mA cm-2 and Tafel slope of 41 mV/decade and excellent durability. communications MWCNTs self-assemble into various homocentric rings in a thermo-driven self-assembly system. Closely packed and scatteredly packed MWCNT rings self-assemble on a Si-SiO 2 substrate, whereas on a Au substrate ...

An injectable, NIR-II light-modulated thermosensitive hydrogel is synthesized through supramolecular self-assembly for light-triggered cisplatin release and repeated chemo-photothermal therapy.

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