Bioadhesives act as a bridge in wound closure by forming an effective interface to protect against liquid and gas leakage and aid the stoppage of bleeding. To their credit, tissue adhesives have made an indelible impact on almost all wound-related surgeries. Their unique properties include minimal damage to tissues, low chance of infection, ease of use and short wound-closure time. In contrast, classic closures, like suturing and stapling, exhibit potential additional complications with long operation times and undesirable inflammatory responses. Although tremendous progress has been made in the development of tissue adhesives, they are not yet ideal. Therefore, highlighting and summarizing existing adhesive designs and synthesis, and comparing the different products will contribute to future development. This review first provides a summary of current commercial traditional tissue adhesives. Then, based on adhesion interaction mechanisms, the tissue adhesives are categorized into three main types: adhesive patches that bind molecularly with tissue, tissue-stitching adhesives based on pre-polymer or precursor solutions, and bioinspired or biomimetic tissue adhesives. Their specific adhesion mechanisms, properties and related applications are discussed. The adhesion mechanisms of commercial traditional adhesives as well as their limitations and shortcomings are also reviewed. Finally, we also discuss the future perspectives of tissue adhesives.

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A conductive engineered cardiac patch (ECP) can reconstruct the biomimetic regenerative microenvironment of an infarcted myocardium. Direct ink writing (DIW) and 3D printing can produce an ECP with precisely controlled microarchitectures. However, developing a printed ECP with high conductivity and flexibility for gapless attachment to conform to epicardial geometry remains a challenge. Herein, an asymmetrical DIW hydrophobic/hydrophilic membrane using heat‐processed graphene oxide (GO) ink is developed. The “Masked spin coating” method is also developed that leads to a microscale GO (hydrophilic)/reduced GO (rGO, hydrophobic) physiological sensor, as well as a macroscale moisture‐driven GO/rGO actuator. Depositing mussel‐inspired polydopamine (PDA) coating on the one side of the DIW rGO , the ultrathin (approximately 500 nm) PDA‐rGO (hydrophilic)/rGO (hydrophobic) microlattice (DrGOM) ECP is bestowed with the flexibility and moisture‐responsive actuation that allows gapless attachment to the curved surface of the epicardium. Conformable DrGOM exhibits a promising therapeutic effect on rats' infarcted hearts through conductive microenvironment reconstruction and improved neovascularization.

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