A highly efficient asymmetric hydrogenation
of γ- and δ-ketoacids was developed by using a chiral
spiro iridium catalyst (S)-1a, affording
the optically active γ- and δ-hydroxy acids/lactones in
high yields with excellent enantioselectivities (up to >99% ee)
and turnover numbers (TON up to 100000). This protocol provides an
efficient and practical method for enantioselective synthesis of Ezetimibe.
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