The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global academic and industrial communities. With the explosive accumulation of multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands and updates core database resources by big data archive, integrative analysis and value-added curation. In the past year, efforts have been devoted to integrating multiple omics data, synthesizing the growing knowledge, developing new resources and upgrading a set of major resources. Particularly, several database resources are newly developed for infectious diseases and microbiology (MPoxVR, KGCoV, ProPan), cancer-trait association (ASCancer Atlas, TWAS Atlas, Brain Catalog, CCAS) as well as tropical plants (TCOD). Importantly, given the global health threat caused by monkeypox virus and SARS-CoV-2, CNCB-NGDC has newly constructed the monkeypox virus resource, along with frequent updates of SARS-CoV-2 genome sequences, variants as well as haplotypes. All the resources and services are publicly accessible at https://ngdc.cncb.ac.cn.

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Novel coronary pneumonia (COVID-19) is a respiratory distress syndrome caused by a new type of coronavirus. The disease began to break out in Wuhan, China, at the end of 2019, and officially entered the global pandemic phase in April 2020. Until now, it is still in a pandemic stage in a number of countries. 1-3 So far, the cumulative number of deaths due to COVID-19 worldwide has reached 1 870 000. The COVID-19 is the direct cause of the current global political and economic turmoil. From an epidemiological perspective, an important feature of COVID-19 is that a considerable proportion of population can turn into a state of asymptomatic or mild illness for a long time after being infected with the virus, while a small proportion quickly enter the moderate or severe stage. 4