HbA1c is an effective and convenient method for diagnosing diabetes and prediabetes. HbA1c thresholds of 6.4% and 6.1% may be used as diagnostic criteria for diabetes and prediabetes, respectively, in the Han Chinese population living in northwest China.

Introduction: Diabetic cardiomyopathy is a cardiac dysfunction in patients with diabetes which may lead to overt heart failure and death. Toll-like receptor (TLR) signaling triggers diabetic cardiomyopathy through various mechanisms, one of which is the upregulation of TLR4 expression. The aim of this study was to delineate the role of TLR4 in diabetic cardiomyopathy. Methods: C57BL/6 mice were injected with streptozotocin to induce diabetes. The experimental and control groups were treated with 5 lg of TLR4 small interfering RNA (siRNA) or scrambled siRNA. Cardiac histopathology was Digital Features To view digital features for this article go to

Objective: To explore the predictive value of the triglyceride glucose-body mass index (TyG-BMI) in relation to the occurrence of non-alcoholic fatty liver disease (NAFLD) in the Chinese population with type 2 diabetes (T2D). Methods: We selected 826 patients with T2D who were hospitalized at the Department of Endocrinology and Metabolism of Karamay People's Hospital from September 2016 to October 2018 for this research. The height, weight, fasting blood glucose, serum insulin, and lipid profiles of the subjects were collected. Stepwise logistic regression analysis was performed to calculate the triglyceride glucose (TyG) index, TyG-BMI, and the ratio of the insulin resistance index (HOMA-IR) to triglyceride high-density lipoprotein-cholesterol at risk for non-alcoholic fatty liver disease. The curve method was used to analyze its predictive value for non-alcoholic fatty liver. Results Results of the logistic regression analysis showed that the risk ratios of NAFLD were 6.54 (3.70-11.53) and 4.868 (2.576-9.200) for the TyG-BMI before and after correction. The area under the curve (AUC) for TyG-BMI was 0.727 (0.691–0.764), which was the highest among all the other parameters studied. Conclusion Compared with the TyG index, the TG/HDL-C, HOMA-IR, and the TyG-BMI are more effective predictors of NAFLD in T2D.