miRNAs are closely associated with tumor genesis and development. The present study investigated the role of the expression of miRNA-766 in the survival of patients with colon cancer and the underlying molecular mechanisms. Reverse transcription-quantitative polymerase chain reaction analysis and microarray analysis were used to analyze the expression of miRNA-766. The results revealed that the expression of miRNA-766 was decreased in patients with colon cancer. The overall survival and disease-free survival rates of patients with colon cancer with a high expression of miRNA-766 were prolonged, compared with those with a low expression of miRNA-766. The overexpression of miRNA-766 reduced cell growth and induced apoptosis in colon cancer cells through suppression of the MDM4/p53 pathway. By contrast, the downregulation of miRNA-766 promoted cell growth and reduced apoptosis in colon cancer cells through activation of the MDM4/p53 pathway. The promotion of MDM4 attenuated the anticancer effect of miRNA-766 in colon cancer cells. These results demonstrated that miRNA-766 induced cell apoptosis in human colon cancer through MDM4/p53.

The 2016 Kumamoto earthquake, including two large (Mw ≥ 6.0) foreshocks and an Mw 7.0 mainshock, occurred in the Hinagu and Futagawa fault zones in the middle of Kyushu island, Japan. Here, we obtain the complex coseismic deformation field associated with this earthquake from Advanced Land Observation Satellite-2 (ALOS-2) and Sentinel-1A Interferometric Synthetic Aperture Radar (InSAR) data. These InSAR data, in combination with available Global Positioning System (GPS) data, are then used to determine an optimal four-segment fault geometry with the jRi method, which considers both data misfit and the perturbation error from data noise. Our preferred slip distribution model indicates that the rupture is dominated by right-lateral strike-slip, with a significant normal slip component. The largest asperity is located on the northern segment of the Futagawa fault, with a maximum slip of 5.6 m at a 5–6 km depth. The estimated shallow slips along the Futagawa fault and northern Hinagu fault are consistent with the displacements of surface ruptures from the field investigation, suggesting a shallow slip deficit. The total geodetic moment release is estimated to be 4.89 × 1019 Nm (Mw 7.09), which is slightly larger than seismological estimates. The calculated static Coulomb stress changes induced by the preferred slip distribution model cannot completely explain the spatial distribution of aftershocks. Sensitivity analysis of Coulomb stress change implies that aftershocks in the stress shadow area may be driven by aseismic creep or triggered by dynamic stress transfer, requiring further investigation.

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