A novel extraction technique was reported. The solid phase material, nanofiber, was prepared by electrospinning using polystyrene. Twenty different drugs (10 microg/L in water) were extracted using 1 mg of nanofibers within 5 min. The analytes can be desorpted from the fibers with 50 microL of the methanol and then monitored by LC coupled to a UV detector. Packed-fiber SPE (PFSPE) provide high recoveries (>50%) for some relatively non-polar drugs (log P >1.5) (n-octanol-to-water partition ratio), and relatively low recoveries (9.9-39.8%) for the drugs within the log P window below 1. Experimental optimization of the technique has been carried out using seven representative drugs, edaravone, cinchonine, quinine, voriconazole, chlordiazepoxide, verapamil, and rutonding. Except for edaravone, the maximum yields of seven drugs (0.2 microg/L) from water samples were approximately 100%, and were 33.7-88.2% from human plasma. The advantageous aspect of the technique encompasses high throughput, high sensitivity, simplicity, low cost, and green chemistry.

The adsorbed PVP enhances further the MOR activity on the O/T but suppresses it on the cubic Pt NPs.

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presented his invited discussion remarks ("Sub-nanometer ligand asymmetry leads to Janus-like nanoparticle membranes"): We had interesting presentations on the mechanical properties of self-assembled nanoparticle membranes and the optical properties of nanodisks. The ligand dynamics and conformation play a key role in dictating the properties of these self-assembled structures. To explore the ligand dynamics, we have performed coarse-grained molecular dynamics simulations of the self-assembly process. We nd that the ligand shell around the self-assembled nanoparticle membranes has an asymmetric distribution with the density being higher at the air-facing side. The presence of this asymmetry leads to the folding of membranes into tubes when exposed to e-beams, as observed experimentally by the rst speaker of this session. 1 Coarse-grained simulations further suggest that the asymmetry originates due to mobility of the ligands on the nanoparticle surface, and is a strong function of the ligand coverage. The ndings of our simulations are corroborated by X-ray scattering studies. Our experimental and simulation study demonstrates that a small change in molecular distribution can impact the macroscopic properties of self-assembled nanostructures.