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The aberrant expression and dysfunction of long non‐coding RNAs (lncRNAs) have been identified as critical factors governing the initiation and progression of different human cancers, including diffuse large B‐cell lymphoma (DLBCL). LncRNA small nucleolar RNA host gene 16 (SNHG16) has been recognized as a tumour‐promoting factor in various types of cancer. However, the biological role of SNHG16 and its underlying mechanism are still unknown in DLBCL. Here we disclosed that SNHG16 was overexpressed in DLBCL tissues and the derived cell lines. SNHG16 knockdown significantly suppressed cell proliferation and cell cycle progression, and it induced apoptosis of DLBCL cells in vitro. Furthermore, silencing of SNHG16 markedly repressed in vivo growth of OCI‐LY7 cells. Mechanistically, SNHG16 directly interacted with miR‐497‐5p by acting as a competing endogenous RNA (ceRNA) and inversely regulated the abundance of miR‐497‐5p in DLBCL cells. Moreover, the proto‐oncogene proviral integration site for Moloney murine leukaemia virus 1 (PIM1) was identified as a novel direct target of miR‐497‐5p. SNHG16 overexpression rescued miR‐497‐5p‐induced down‐regulation of PIM1 in DLBCL cells. Importantly, restoration of PIM1 expression reversed SNHG16 knockdown‐induced inhibition of proliferation, G0/G1 phase arrest and apoptosis of OCI‐LY7 cells. Our study suggests that the SNHG16/miR‐497‐5p/PIM1 axis may provide promising therapeutic targets for DLBCL progression.

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The catalytic performance in heterogeneous catalytic reactions consisting of solid reactants is strongly dependent on the nanostructure of the catalysts. Metal-oxides core-shell (MOCS) nanostructures have potential to enhance the catalytic activity for soot oxidation reactions as a result of optimizing the density of active sites located at the metal-oxide interface. Here, we report a facile strategy for fabricating nanocatalysts with self-assembled Pt@CeO-rich core-shell nanoparticles (NPs) supported on three-dimensionally ordered macroporous (3DOM) CeZrOvia the in situ colloidal crystal template (CCT) method. The nanostructure-dependent activity of the catalysts for soot oxidation were investigated by means of SEM, TEM, H-TPR, XPS, O-isothermal chemisorption, soot-TPO and so on. A CeO-rich shell on a Pt core is preferentially separated from CeZrO precursors and could self-assemble to form MOCS nanostructures. 3DOM structures can enhance the contact efficiency between catalysts and solid reactants (soot). Pt@CeO-rich core-shell nanostructures can optimize the density of oxygen vacancies (O) as active sites located at the interface of Pt-CeZrO. Remarkably, 3DOM Pt@CeO-rich/CeZrO catalysts show super catalytic performance and strongly nanostructure-dependent activity for soot oxidation in the absence of NO and NO. For example, the T of the 3DOM Pt@CeO-rich/CeZrO catalyst is lowered down to 408 °C, and the reaction rate of the 3DOM Pt@CeO-rich/CeZrO catalyst (0.12 μmol g s) at 300 °C is 4 times that of the 3DOM Pt/CeZrO catalyst (0.03 μmol g s). The structures of 3DOM CeZrO-supported Pt@CeO-rich core-shell NPs are decent systems for deep oxidation of solid reactants or macromolecules, and this facile technique for synthesizing catalysts has potential to be applied to other element compositions.