Two new quaternary isoquinoline alkaloids, saxicolalines A (1) and N-methylnarceimicine (2), together with sixteen known alkaloids (3 - 18) were isolated from Corydalis saxicola Bunting. The structures of saxicolalines A (1) and N-methylnarceimicine (2) were established based on spectral methods including 1D, 2D NMR (COSY, HMQC, HMBC) and HR-ESI-MS. The anti-HBV activities of ten main alkaloids were evaluated. Among the tested compounds, dihydrochelerythrine (8) exhibited the most potent activity against HBsAg and HBeAg secretions with IC50 < 0.05 microM, SI > 3.5, respectively.

Free radical scavengers or antioxidants are currently forged as the drug candidates to counter many diseases, such as drug-associated toxicity, inflammation, atherogenesis and aging in aerobic organisms [1][2][3] . Thus the significance of free radicals in the pathogenesis of various diseases has attracted considerable interest. Minor dietary compositions have been considerably deemed to combat the ill effects of free radicals. In addition, since that what may be learn from natural plants could overcome the toxicity problem of synthetic radical scavengers or antioxidants, so isolation of natural radical scavengers or antioxidants from natural plants has become a popular method.Abies yuanbaoshanensis, which distributed in Rongshui county in Guangxi Province of China, is a peculiar endangered precious plant. The pharmacological research has showed that it possess of wide biological activities 4 , including antitumor, antibacterial, antifungal, antiinflammatory and antitussive activities. Previous studies have indicated that various diseases such as antitumor, antibacterial and antifungal are characteristically associated with free radicals and ROS 5 . It is possible that some constitutes of Abies yuanbaoshanensis should get good free radical scavenging activities. So herein the extraction and radical-scavenging activities of Abies yuanbaoshanensis was studied.Abies yuanbaoshanensis were collected from Rongshui county of Guangxi Zhuang Autonomous Region in China, in July 2009 and verified by Prof. Zong-Ming Su. The air-dried needles and stems of Abies yuanbaoshanensis (10 Kg

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