Indians undergoing socioeconomic and lifestyle transitions will be maximally affected by epidemic of type 2 diabetes (T2D). We conducted a two-stage genome-wide association study of T2D in 12,535 Indians, a less explored but high-risk group. We identified a new type 2 diabetes–associated locus at 2q21, with the lead signal being rs6723108 (odds ratio 1.31; P = 3.32 × 10−9). Imputation analysis refined the signal to rs998451 (odds ratio 1.56; P = 6.3 × 10−12) within TMEM163 that encodes a probable vesicular transporter in nerve terminals. TMEM163 variants also showed association with decreased fasting plasma insulin and homeostatic model assessment of insulin resistance, indicating a plausible effect through impaired insulin secretion. The 2q21 region also harbors RAB3GAP1 and ACMSD; those are involved in neurologic disorders. Forty-nine of 56 previously reported signals showed consistency in direction with similar effect sizes in Indians and previous studies, and 25 of them were also associated (P < 0.05). Known loci and the newly identified 2q21 locus altogether explained 7.65% variance in the risk of T2D in Indians. Our study suggests that common susceptibility variants for T2D are largely the same across populations, but also reveals a population-specific locus and provides further insights into genetic architecture and etiology of T2D.

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Thirty genotypes of fenugreek (<italic>Trigonella foenum-graecum</italic> L.) were evaluated over four environments in randomized block design with 3 replications to estimate stability parameters of seed yield and its important component traits. The environments were created by changing the dates of sowing and irrigation levels. The genotypes interacted with the environments significantly indicating non linear response of genotypes to environments. Simple correlations between seed yield and other traits indicated that pods per plant and the test weight are the two important component traits. Stability analysis indicated difference in stability among the genotype for seed yield and the component traits. A positive correlation was noted between the regression coefficient and the mean seed yield of the genotypes, thus hypothesizing that higher yielding genotypes were better suited to better environments. The results of AMMI analysis corroborated with the results obtained from stability anlaysis, although AMMI analysis provided a better chance to delineate the genotypes and environments. Genotypes UM-137, UM-128, UM-322 and RMt-1 are found relatively stable for seed yield.