This study was aimed to evaluate the synaptic plasticity in projections from the dorsal lateral region (Dl) to the bilateral dorsal medial region (Dm) of the zebrafish telencephalon. The results showed that unilateral electrical stimulation of the Dl evokes a negative field potential (FP) in both the contralateral and ipsilateral side of the Dm. We tested synaptic plasticity, including high-frequency stimulation-induced LTP (HFS-LTP) and low-frequency stimulation-induced LTD (LFS-LTD). We demonstrated that HFS-induced bilateral LTP is NMDAR-dependent by the application of an NMDAR antagonist, DL-AP5 (30 μM, suprafused for 10 min), which blocked the HFS-induced LTP in both the contralateral and ipsilateral Dm. In addition, LTP was restored after DL-AP5 was washed out by continuous aCSF suprafusion. These results suggested that the potentiation is NMDAR-dependent. Either LFS (1 Hz for 20 min) or applying the mGluR agonist, DHPG (40 μM, suprafused for 10 min) successfully induced bilateral LTD for at least 1 h. Furthermore, both the contralateral fEPSP and LTP vanished after ablation of the anterior commissure. In conclusion, the results of the present study suggested that the projection between the Dl and contralateral Dm in the telencephalon of zebrafish is via the anterior commissure and possesses synaptic plasticity.

ObjectiveThe purpose of this study was to construct a computerized adaptive test (CAT) for measuring self-care performance (the CAT-SC) in children with developmental disabilities (DD) aged from 6 months to 12 years in a content-inclusive, precise, and efficient fashion.MethodsThe study was divided into 3 phases: (1) item bank development, (2) item testing, and (3) a simulation study to determine the stopping rules for the administration of the CAT-SC. A total of 215 caregivers of children with DD were interviewed with the 73-item CAT-SC item bank. An item response theory model was adopted for examining the construct validity to estimate item parameters after investigation of the unidimensionality, equality of slope parameters, item fitness, and differential item functioning (DIF). In the last phase, the reliability and concurrent validity of the CAT-SC were evaluated.ResultsThe final CAT-SC item bank contained 56 items. The stopping rules suggested were (a) reliability coefficient greater than 0.9 or (b) 14 items administered. The results of simulation also showed that 85% of the estimated self-care performance scores would reach a reliability higher than 0.9 with a mean test length of 8.5 items, and the mean reliability for the rest was 0.86. Administering the CAT-SC could reduce the number of items administered by 75% to 84%. In addition, self-care performances estimated by the CAT-SC and the full item bank were very similar to each other (Pearson r = 0.98).ConclusionThe newly developed CAT-SC can efficiently measure self-care performance in children with DD whose performances are comparable to those of TD children aged from 6 months to 12 years as precisely as the whole item bank. The item bank of the CAT-SC has good reliability and a unidimensional self-care construct, and the CAT can estimate self-care performance with less than 25% of the items in the item bank. Therefore, the CAT-SC could be useful for measuring self-care performance in children with DD in clinical and research settings.

The aim of this study was to understand how to process Yoga headstand and the difference between genders in headstand. Twelve skilled participates were recruited in this study (Males 34.1 [Formula: see text] 3.3 years, [Formula: see text]; Females 36.5 [Formula: see text] 3.9 years, [Formula: see text]). The 10 camera Vicon motion capture system, Kistler force plate, and Medilogic pressure mat were used synchronously to record the movement, ground reaction force, and pressure distribution during headstand. The Mann–Whitney U test and Friedman test ([Formula: see text]) was applied to assess the statistics. The trunk, hip, knee, and ankle joint angles were [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text], respectively, in all subjects. The pressure distribution was 38 [Formula: see text] 19%, 29 [Formula: see text] 12%, and 33 [Formula: see text] 9% on subjects’ heads, right elbows, and left elbows, respectively. The COP trajectory was 31.2 [Formula: see text] 17.4[Formula: see text]cm and surface area was 5.3 [Formula: see text] 1.4[Formula: see text]cm2. No significant differences were found in joint angles, overall force distribution, and COP trajectory and surface area between genders. Both males and females distribute body weight to the supports of head and elbows equally and kept the body straight and erect on the ground during Yoga headstand.

The 3D model of 100T bridge-craft was created using Pro/E, and FEM analysis was carried out based on ANSYS. Distribution of stress and deformation was obtained. The results agree with the results obtained by the experiment. And it can be used as a reference for optimizing the bridge-craft structure.