We have developed a glucose-responsive metal-organic framework (MOF)-based insulin delivery nanosystem via a one-pot process. The system relies on the MOF response to glucose stimulation and this can promote insulin delivery. This nanosystem was successfully applied for glucose-responsive and self-regulated insulin release.

A label-free nanozyme MIL-53(Fe) with the dual-function of catalyzing and emitting fluorescence was utilized for turn-on fluorescence detection of hydrogen peroxide and glucose. The proposed strategy provides a cost-effective, safe and sensitive method for the design and development of multiple enzyme cascade assays for various biomolecules.

Artificial enzymes is an emerging field of research owing to the remarkable advantages of enzyme mimics over their natural counterpart, including tunable catalytic efficiencies, lower cost, ease of preparation, and excellent tolerance to variations of the reaction system. Herein, we report an efficient peroxidase mimic based on a copper-modified covalent triazine framework (CCTF). Owing to its unique specific surface area, atomically dispersed active Cu sites, efficient electron transfer, and enhanced photo-assisted enzyme-like activity, the CCTF showed enhanced peroxidase-like enzyme activity. Therefore, copper modification represents an effective route to tailor the peroxidase-like activity of the covalent triazine frameworks. Furthermore, the mechanism of the enhanced peroxidase-like activity and stability of the CCTF were investigated. As a proof of concept, the CCTF was used for the colorimetric detection of H O and decomposition of organic pollutants. This work provides a new strategy for the design of enzyme mimics with a broad range of potential applications.

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