Fabrication of high-performance artificial antioxidant enzyme (AAE) systems based on a single nanozyme possessing multi-enzymatic activities is fascinating but challenging. Here, polyvinylpyrrolidone (PVP)–platinum–copper nanoparticle clusters (PVP-PtCuNCs) are prepared by a facile one-pot chemical coreduction method. PVP-PtCuNCs possess efficient superoxide dismutase (SOD)-like, peroxidase (POD)-like, and catalase (CAT)-like activities, and the multi-enzymatic activities depend on the bimetal component and cluster structure. Compared with individual platinum nanoparticle clusters (PVP-PtNCs), PVP-PtCuNCs can effectively eliminate reactive oxygen species (ROS) including superoxide anions, hydrogen peroxide, and hydroxyl radicals. The doping of copper not only reduces the usage of Pt content but also improves the catalytic efficiency and versatility effectively through the synergistic effect of bimetal components and the nanocluster structure. The results not only demonstrate that a single bimetallic nanozyme has the potential as an efficient AAE system in the biomedical application but also demonstrate that traditional concepts of structure–activity relationships can be used to fabricate nanozymes with the desired multi-enzymatic activities.

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There are HBV quasi species in the sera of AsCs, and the mutations are related to virus load and hepatitis B e antigen seroconversion, irrespective of age.

The complete mitochondrial genome sequence of Hepialus gonggaensis was sequenced for the first time. The complete mtDNA sequence was 15,940 bp in length and contained 13 protein-coding genes, two rRNA genes, 22 tRNA genes, and an AT-rich region, the gene composition and the arrangement of which were identical to other insects of Hepialidae. The overall base composition of the heavy strand was 41.14% A, 40.24% T, 11.17% C, and 7.45% G, with an AT content of 81.37%. The necleotide sequence data of 13 protein-coding genes of H. gonggaensis and other 10 Lepidoptera species were used for constructing the phylogenetic tree. It revealed that H. gonggaensis and other four Hepialidae species were clustered to a clade with high bootstraps values.