The oral pharmacokinetics of three sulfonamides, sulfadimidine (pKa 7.5), sulfadiazine (pKa 6.5) and sulfanilamide (pKa 10.5), with different rates of unionization in rumen juice, were compared in Shiba goats to clarify the relationship between drug absorption profiles after their oral administration as well as their degree of unionization in the rumen. Sulfonamides were administered either into the left jugular vein or orally to five male goats at doses of 10 mg/kg body weight, using a crossover design with at least a 3-week washout period. The Tmax of sulfadimidine, sulfadiazine and sulfanilamide reached 2.0 ± 1.2, 6.0 ± 0.0, and 7.8 ± 1.6 hr, respectively, after their oral administration, and this was followed by their slow elimination due to a slow rate of drug absorption from the gastrointestinal tract. The MAT and t1/2ka of sulfadiazine (13.2 ± 2.0 and 10.9 ± 1.08 hr) were significantly longer than those of sulfanilamide (9.09 ± 1.67 and 7.46 ± 1.70 hr) and sulfadimidine (7.52 ± 0.85 and 5.17 ± 0.66 hr). These results suggest that the absorption rates of highly unionized drugs (such as sulfanilamide and sulfadimidine) from the forestomach of goats may be markedly higher than less unionized ones (such as sulfadiazine). The mean oral bioavailability of sulfadiazine was high (83.9 ± 17.0%), whereas those of sulfadimidine and sulfanilamide were low (44.9 ± 16.4% and 49.2 ± 2.11%, respectively).

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We investigate torsional chiral magnetic effect (TCME) induced by skyrmion-vortex textures in the A phase of the superfluid 3 He. In 3 He-A, Bogoliubov quasiparticles around point nodes behave as Weyl fermions, and the nodal direction represented by the ℓ-vector may form a spatially modulated texture. ℓ-textures generate a chiral gauge field and a torsion field directly acting on the chirality of Weyl-Bogoliubov quasiparticles. It has been clarified by G. E. Volovik [Pi'sma Zh. Eksp. Teor. Fiz. 43, 428 (1986)] that, if the ℓ-vector is twisted asl · (curll) 0, the chiral gauge field is responsible for the chiral anomaly, leading to an anomalous current along ℓ. Here we show that, even ifl·(curll) = 0, a torsion arising from ℓ-textures brings about contributions to the equilibrium currents of Weyl-Bogoliubov quasiparticles along curlℓ. This implies that while the anomalous current appears only for the twisted (Bloch-type) skyrmion of the ℓ-vector, the extra mass current due to TCME always exists regardless of the skyrmion type. Solving the Bogoliubov-de Gennes equation, we demonstrate that both Bloch-type and Néel-type skyrmions induce chiral fermion states with spectral asymmetry, and possess spatially inhomogeneous structures of Weyl bands in the real coordinate space. Furthermore, we discuss the contributions of Weyl-Bogoliubov quasiparticles and continuum states to the mass current density in the vicinity of the topological phase transition. In the weak coupling limit, continuum states give rise to backflow to the mass current generated by Weyl-Bogoliubov quasiparticles, which makes a non-negligible contribution to the orbital angular momentum. As the topological transition is approached, the mass current density is governed by the contribution of continuum states.II. TORSIONAL CHIRAL MAGNETIC EFFECT AND SEMICLASSICAL ANALYSIS A. Semiclassical equation of motion for Weyl-Bogoliubov quasiparticlesWe consider the Bogoliubov-de Gennes (BdG) Hamiltonian for the Bogoliubov quasiparticles in the A-phase of the superfluid 3 He, i.e., a three-dimensional (3D) chiral p + ip super-

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