We present a catalog of 9017 X-ray sources identified in Chandra observations of a 2×0.8 • field around the Galactic center. This enlarges the number of known X-ray sources in the region by a factor of 2.5. The catalog incorporates all of the ACIS-I observations as of 2007 August, which total 2.25 Msec of exposure. At the distance to the Galactic center (8 kpc), we are sensitive to sources with luminosities of 4 × 10 32 erg s −1 (0.5-8.0 keV; 90% confidence) over an area of one square degree, and up to an order of magnitude more sensitive in the deepest exposure (1.0 Msec) around Sgr A * . The positions of 60% of our sources are accurate to <1 ′′ (95% confidence), and 20% have positions accurate to <0. ′′ 5. We search for variable sources, and find that 3% exhibit flux variations within an observation, 10% exhibit variations from observation-to-observation. We also find one source, CXOUGC J174622.7-285218, with a periodic 1745 s signal (1.4% chance probability), which is probably a magnetically-accreting cataclysmic variable. We compare the spatial distribution of Xray sources to a model for the stellar distribution, and find 2.8σ evidence for excesses in the numbers of X-ray sources in the region of recent star formation encompassed by the Arches, Quintuplet, and Galactic center star clusters. These excess sources are also seen in the luminosity distribution of the X-ray sources, which is flatter near the Arches and Quintuplet than elsewhere in the field. These excess point sources, along with a similar longitudinal asymmetry in the distribution of diffuse iron emission that has been reported by other authors, probably have their origin in the young stars that are prominent at l≈0.1 • .

International audienceWe present infrared observations of 3C 58 with the Spitzer Space Telescope and the Canada-France-Hawaii Telescope. Using the IRAC camera, we have imaged the entire source, which results in clear detections of the nebula at 3.6 and 4.5 μm. The derived flux values are consistent with extrapolation of the X-ray spectrum to the infrared band, demonstrating that any cooling break in the synchrotron spectrum must occur near the soft X-ray band. We also detect the torus surrounding PSR J0205+6449, the 65 ms pulsar that powers 3C 58. The torus spectrum requires a break between the infrared and X-ray bands, and perhaps multiple breaks. This complex spectrum, which is an imprint of the particles injected into the nebula, has considerable consequences for the evolution of the broadband spectrum of 3C 58. We illustrate these effects and discuss the impact of these observations on the modeling of broadband spectra of pulsar wind nebulae

No abstract

The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both in vitro and in vivo conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.

Fibronectin (FN) is a cell adhesion protein that binds integrins in a process also involving the protein-crosslinking enzyme transglutaminase 2 (TG2) as a co-receptor. The cell-adhesive property of TG2 has been linked to a complex formation with FN and to its ability to crosslink and polymerize FN on the cell surface. We tested here the effects of extracellular FN, before and after in vitro crosslinking and polymerization by TG2, on MC3T3-E1 osteoblast adhesion. We show that TG2-mediated crosslinking creates large, compacted chain-like protein clusters that include both TG2 and FN molecules as analyzed by Western blotting and atomic force microscopy. Crosslinking of FN significantly promotes osteoblast adhesion as measured by crystal violet staining, and enhances beta(1)-integrin clustering on the cell surface as visualized by immunofluorescence microscopy. We hypothesize that TG2-mediated crosslinking enhances the cell-adhesive properties of FN by increasing the molecular rigidity of FN in the extracellular matrix.