Efficient management of providing home health care services requires many considerations. In this paper, a mathematical model for the daily staff routing and service scheduling is developed for home health care companies. In this model, both economic factors and qualitative serviceoriented performance measures are simultaneously optimized. To make the model more realistic, many real situations such as considering different qualifications and diverse vehicles for staff members, different requirements and predetermined preferences for patients, possible temporal interdependencies between services, and continuity of care (CoC) are taken into account. We also added some important constraints related to blood sampling requirements, which make our proposed model more complex. The proposed model is a mixed integer linear programming (MILP) model that belongs to an NP-hard class of optimization problems. To solve such a complex mathematical model, a genetic algorithm (GA) is proposed to find near-optimal 2 solutions. We use some randomly generated test instances with different sizes to evaluate the performance of the GA. Finally, it is demonstrated how the proposed solution scheme can end up with proper scheduling and routing policies compared to those obtained through exact methods.

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Introduction: The increase in immobility in all sections of society, especially children and adolescents, has become one of the most important concerns in the health status of this age group. Aim: The main purpose of this study was to investigate the effect of watching models of teaching physical activity on cognitive-motor components and physical competence among children. Method: The current research was a semi-experimental study with two experimental and control groups. The statistical population included all 8-10 year-old boy students of Khoi city in the academic year of 2021-2022. 30 males with aged 8-10 years were voluntarily selected and randomly divided into two experimental groups and one control group. To data collection, we used the Canadian Physical Literacy Assessment Tool (CAPL), Physical Fitness Scale, Progressive Aerobic Fitness Test, Health-Related Physical Fitness Test and Basic Physical Education Training. Univariate and multivariate analysis of covariance were used to compare the groups using SPSS-20. Results: The results of the covariance test showed that virtual education using watching video models and teaching the basic concepts of physical activity have a significant positive effect on the physical competence and cognitive-motor dimensions among children aged 8 to 10 years (P<0.05). Also, the results showed that the group effect is significant (P=0.001, Eta square=0.70, F=56.65). Therefore, the amount of cognitive-motor dimension in the post-test has a significant difference. Conclusion: Based on the results, the virtual education using watching video models and teaching the basic concepts of physical activity increases cognitive-motor function, physical literacy and physical activity among children. Therefore, researchers, teachers and parents of children are recommended to use this method of education to improve the level of physical activity and cognitive-behavioral components of children.

Minocycline, widely used as an antibiotic, has recently been found to have an anti-inflammatory, neuroprotective and anticonvulsant effects. This study was aimed to investigate the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole (PTZ)-induced seizures considering the possible involvement of 5-HT3 receptor in this effect. For this purpose, seizures were induced by intravenous PTZ infusion. All drugs were administrated by intraperitoneal (i.p.) route before PTZ injection. Also, 1-(m-chlorophenyl)-biguanide (mCPBG, a 5-HT3 receptor agonist) and Tropisetron (a 5-HT3 receptor antagonist) were used 45 minutes before minocycline treatment. Our results demonstrate that acute minocycline treatment (80 and 120 mg/kg) increased the seizure threshold. In addition, the 5-HT3 antagonist, tropisetron, at doses that had no effect on seizure threshold, augmented the anticonvulsant effect of minocycline (40 mg/kg), while mCPBG (0.2 mg/kg) blunted the anticonvulsant effect of minocycline (80 mg/kg). In conclusion, our findings revealed that the anticonvulsant effect of minocycline is mediated, at least in part, by inhibition of 5-HT3 receptor.

The purpose of this study was investigating of contextual interference (CI) effects in observational learning. Therefore, verbal and visual cueing related to correction of technique were organized in blocked and random methods. Participants (n=24, age=19 ± 1.4) were set randomly in one of the blocked, random or control group. Performances were captured with 3-DMotion Analysis System and analyzed by Cortex Software. result of Mixed Anova 3 (group) × 3 (day) of Fisher z scales mean from the Pearson correlation between participants and model kinematic data, showed that in acquisition of hip (p=0.29) and ankle (p=0.30) angles pattern, there were no significant different between groups. But for knee angle (p=0.01), the group that received verbal and visual cueing by random, had most similarity with model performance and the blocked group, had least similarity with model performance. Then, CI is also beneficial in observation context. Therefore, if the learner watched himself in addition to performing skills between training sessions and focus randomly on each part of body movement, it seems the practice effect would increase because the learner is involved actively in the learning process, and this leads to a more profound processing of information on the movement of any part of the body.