Background: Helicobacter pylori is a major cause of upper gastrointestinal disorders. The eradication of H. pylori has been recommended for the treatment of different gastrointestinal diseases. Notwithstanding, a combination therapy is needed for Helicobacter pylori eradication, but using these medications can be the cause, the incidence risk of patients' adherence to treatment regimens reduction and probably increase risk of Adverse Drug Reactions (ADRS), so, it is seem that evaluation the out come of combination therapy is need more than the past. Aim:The aim of present study was to determine the patients' adher ence to the treatment and the ADRs with five eradiation regimens. Setting and Design:A cross sectional study was done in a well known referral clinic of gastrointestinal disorders in Tehran, Iran. Methods and Materials:Ninety patients were evaluated the study (18 in each of the five regimens). The adherence to the treatment and the ADRs of the patients were asked during the treatment, twice, by doing telephone assays. Statistical Analysis Used:The data were analyzed by using the SPSS, 17 software and the statistical significance was accepted for the P values of 0.05.

Because of the short duration of action of adenosine, catecholamines and niacin seems to be the major role in appearance of adverse events reported in TIM for Herba Portulacae Oleraceae seed. Mechanisms with consideration of receptor types and pharmacokinetics of catecholamine and niacin are warranted to confirm this hypothesis.

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This study showed that most stat orders at Masih Daneshvari Hospital during the study period were prescribed appropriately. Further investigations are recommended to evaluate the outcomes of unnecessary stat orders with respect to adverse drug events.

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