Evaluation of adverse events reported in Traditional Iranian Medicine following administration of aqueous extract of Herba Portulacae Oleraceae seed

Mirabzadeh, Mehran; Sahraee, Zahra; Rahimi, Roja

doi:10.1016/s0254-6272(13)60161-2

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…The mean score of breast fissures significantly decreased and no complications were observed after the patients were treated with Portulaca oleracea L. cream (2%). It is worth noting that adverse events such as itching and tingling of whole body, dyspnea and tachycardia were reported after the systemic administration of Portulaca oleracea seed extract ( Mirabzadeh et al, 2013 ).…”

Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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Chronic and unhealed wound is a serious public problem, which brings severe economic burdens and psychological pressure to patients. Various botanical drugs in traditional Chinese medicine have been used for the treatment of wounds since ancient time. Nowadays, multiple wound healing therapeutics derived from botanical drugs are commercially available worldwide. An increasing number of investigations have been conducted to elucidate the wound healing activities and the potential mechanisms of botanical drugs in recent years. The aim of this review is to summarize the botanical drugs in traditional Chinese medicine with wound healing properties and the underlying mechanisms of them, which can contribute to the research of wound healing and drug development. Taken together, five botanical drugs that have been developed into commercially available products, and 24 botanical drugs with excellent wound healing activities and several multiherbal preparations are reviewed in this article.

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Section: Botanical Drugs In Traditional Chinese Medicine With Wound H...mentioning

confidence: 99%

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

et al. 2022

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“…The seed of P. oleracea, commonly known as purslane is considered as an ancient drug which has been used for the treatment of several diseases such as gastrointestinal ulceration, urinary tract infections, kidney stone and menstruation disorders in traditional and folklore medicine of different countries (Mirabzadeh et al, 2013). It has been suggested that the seeds possess a pronounced antidiabetic activity in recipes of traditional medicines.…”

Section: Portulaca Oleracea (Portulacaceae)mentioning

confidence: 99%

Traditional Medicinal Herbs for the Management of Diabetes and its Complications: An Evidence-Based Review

Farzaei¹,

Rahimi²,

Farzaei³

et al. 2015

International J. of Pharmacology

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A B S T R A C T Diabetes mellitus is a complex metabolic disease associated with impaired insulin secretion, developing insulin resistance as well as β-cell dysfunction, that leads to abnormal glucose, protein and lipid metabolism, inflammatory responses and oxidative damages. Traditional medicines suggest a wide range of remedies for the management of symptomatologies associated with chronic disorders including diabetes mellitus. The aim of the present study is to elicit the most popular traditionally used medicinal plants for diabetes and review literatures in order to scientifically evaluate their efficacy and safety in diabetes mellitus and its complications. In addition, their molecular and cellular mechanisms of action along with active phytochemical agents were highlighted. The findings demonstrated that traditional herbal remedies perform their antidiabetic potential through different cellular and molecular mechanisms, including enhancing insulin secretion, regeneration of pancreatic β-cell, improving insulin resistance, α-glucosidase enzyme inhibitory activity and anti-inflammatory effects as well as attenuating diabetes associated oxidative stress. Suppressing hepatic glucose output and enhancing glucose uptake as key contributors in antidiabetic effect of natural remedies are mediated via stimulating glycolysis, glucose oxidation and glycogenesis, along with reducing glycogen degradation and gluconeogenesis. Since traditional natural remedies are commonly used by diabetic patients, interaction between herbs and conventional antidiabetics has also been highlighted in this study. Overall, traditional herbal remedies are possible antihyperglycemic therapeutic adjuncts and potential source of new orally active agent(s) for management of diabetes; however, more well-designed clinical trials are suggested to recognize higher levels of evidence for the confirmation of their efficacy and safety.

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“…ese properties utterly provide considerable benefits to prevent the heart attacks and strengthening the immune system. Besides, they have favorable effects on cholesterol and triglyceride levels [51][52][53][54][55].…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Persian Herbal Medicine Compound on the Lipid Profiles of Patients with Dyslipidemia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Niknafs

Rezvanfar

Kamalinejad

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Introduction. It has been well established in the world that lipid disorders promote the development of atherosclerosis and its clinical consequences. This study aimed to assess the impacts of a Persian medicinal (PM) compound on lipid profile. Materials and Methods. From June 21 to October 21, 2020, a randomized double-blind controlled clinical trial was conducted with 74 dyslipidemic patients, who were randomly divided into two equally populated groups: one prescribed with a Persian medicinal herbal compound (n = 37) and a placebo group (n = 37). A Persian herbal medicine including fenugreek, sumac, and purslane is introduced. Biochemical parameters including 12-hour fasting serum levels of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglyceride (TG) were measured before the initiation and after the completion of study protocol. Results. Percent changes of biochemical parameters include the following: intervention group = cholesterol: 35.22, Tg: 45.91, LDL: 24.81, HDL: 2.05, VLDL: 8.94 and placebo group = cholesterol: 6.94, Tg: −7.3, LDL: 7.37, HDL: 2.88, VLDL: −0.14. The serum levels of total cholesterol ( p = 0.01 ) and LDL ( p = 0.01 ) significantly decreased and no increase was recorded in HDL ( p = 0.03 ) levels over time in the intervention group. Furthermore, between-group analysis showed a statistically significant difference between the intervention and placebo groups in this regard. VLDL ( p = 0.2 ) and TG ( p = 0.2 ) levels also decreased, however not significantly. Conclusion. This study showed that a Persian medicinal herbal compound could be safe and beneficial to decrease the levels of serum cholesterol and LDL in dyslipidemic patients. However, larger long-term studies are recommended to clarify this effect.

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Evaluation of adverse events reported in Traditional Iranian Medicine following administration of aqueous extract of Herba Portulacae Oleraceae seed

Cited by 7 publications

References 14 publications

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties

Traditional Medicinal Herbs for the Management of Diabetes and its Complications: An Evidence-Based Review

The Effect of a Persian Herbal Medicine Compound on the Lipid Profiles of Patients with Dyslipidemia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

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