A combination of M. officinalis and N. menthoides Boiss. & Buhse could be an alternative sleep improvement therapy.

Because of the short duration of action of adenosine, catecholamines and niacin seems to be the major role in appearance of adverse events reported in TIM for Herba Portulacae Oleraceae seed. Mechanisms with consideration of receptor types and pharmacokinetics of catecholamine and niacin are warranted to confirm this hypothesis.

The effects of vinegar and oxymel solutions (used in Iranian traditional medicine) and processing temperatures (75, 85 and 100°C) on the milk coagulation was studied to identify and determine the protein indicators of resulting whey. The HPLC (high performance liquid chromatography) analysis showed that the α-lactalbumin (ALA) and β-lactoglobulin (BLG) contents of resulting whey reduced significantly, when the coagulation temperature increased from 75 to 100 o C. In both solutions and at 75 o C processing temperature, the BLG of final whey protein was significantly more (~ 60-70 %) than ALA content. The reverse process happened at 85 o C, and the ALA content became much higher than BLG. A significantly higher content of ALA was recovered once the combination of oxymel and vinegar solutions with milk reached to respectivelỹ 10 and 0.3 % and milk protein was coagulated at 85 o C. Overall, there is a good possibility to make a milk whey with high content of desirable ALA and negligible concentrations of BLG to convert cow's milk proteins to human's milk as it was the main intention in Iranian Traditional Medicine method.

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