Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods:This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population.Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion:Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

Psychiatric symptoms, perceived social support, coping styles, and dyadic adjustment in pregnant women with hyperemesis gravidarum Objective: Hyperemesis gravidarum (HG) is a condition with severe nausea and vomiting, which is seen in 0.3-2% of pregnancies. In addition to biological factors, psychosocial factors were also reported to play a role in the development of HG. However, the impact of psychosocial factors in HG has not been elucidated yet. In this research, we aimed to investigate psychiatric symptoms in patients with HG and their relationships with perceived social support, coping styles, and dyadic adjustment. Method: Forty-eight women with HG hospitalized in the Obstetrics and Gynecology Inpatient Unit and 48 healthy pregnant women consulted to the Obstetric Outpatient Unit for their routine obstetric control were recruited for the study. The subjects were evaluated with sociodemographic form, Symptom Check List (SCL-90-R), Multidimensional Scale of Perceived Social Support (MSPSS), Ways of Coping Scale (WCS), and Dyadic Adjustment Scale (DAS). Results: All sociodemographic variables except nausea and vomiting history in previous pregnancies were similar in both groups. All subscales and global symptom index scores of SCL-90-R were higher; optimistic and submissive subscale scores of WCS were lower, satisfaction, consensus and total scores of DAS were higher in HG group (p<0.05). Conclusion: Psychiatric symptom levels are higher in women with HG compared to the controls. No difference for previous psychiatric history among groups shows that previous psychiatric history is not a predictor for HG. The psychiatric symptoms in HG is self-limiting and possibly due to HG symptoms. Psychosocial factors such as perceived social support, coping styles, and dyadic adjustment may contribute to the psychiatric symptoms. Keywords: Coping styles, dyadic adjustment, hyperemesis gravidarum, perceived social support, psychiatric symptoms ÖZET Hiperemezis gravidarumu olan gebelerde ruhsal belirtiler, stresle başa çıkma tarzları, algılanan sosyal destek ve çift uyumu Amaç: Hiperemezis gravidarum (HG), şiddetli bulantı-kusma ile giden ve gebelerin yaklaşık %0.3-2'sinde görülen bir tablodur. Biyolojik etkenler yanında psikososyal etkenlerin de HG gelişiminde rol oynayabileceği bildirilmiştir. Fakat, HG'de psikososyal etkenlerin rolü tam olarak gösterilememiştir. Bu çalışmada HG ile ruhsal belirtiler ve bu belirtilerin algılanan sosyal destek, stresle başa çıkma tarzları ve çift uyumu arasındaki ilişkisini değerlendirmeyi hedefledik. Yöntem: Kadın Hastalıkları ve Doğum Kliniği'nde HG tanısı ile yatırılan 48 gebe ile hastanenin Kadın Hastalıkları ve Doğum polikliniğine rutin doğum öncesi kontroller için başvuran 48 sağlıklı gebe çalışmaya alındı. Denekler, sosyodemografik form, Belirti Tarama Listesi (SCL-90-R), Çok Boyutlu Algılanan Sosyal Destek Ölçeği (ÇBASDÖ), Stresle Başaçıkma Tarzları Ölçeği (SBTÖ) ve Çift Uyum Ölçeği (ÇUÖ) ile değerlendirildi. Bulgular: Bulantı kusma öyküsü dışında tüm sosyodemografik değişk...

Background/aim: To investigate whether spontaneous preterm labor (PTL) with intact membranes is associated with changes in maternal serum prohepcidin concentrations. Materials and methods:The study consisted of patients with spontaneous PTL with intact membranes (n = 25), a control group of healthy pregnant women between the 24th and 37th gestational weeks (n = 22), and uncomplicated term pregnancies in spontaneous labor (n = 19). Blood samples were collected from patients at the time of clinical diagnosis. Levels of prohepcidin, hemoglobin, serum ferritin, serum iron, unsaturated iron binding capacity, total iron binding capacity, transferrin and transferrin saturation, C reactive protein, and interleukin-6 were measured.Results: Patients with spontaneous PTL had significantly lower maternal serum prohepcidin concentrations than term delivery and control subjects. Conclusion:Maternal serum prohepcidin concentration is lower in patients with spontaneous PTL compared to term delivery and control subjects. This suggests that measuring maternal serum prohepcidin concentrations in PTL may be a feasible method for understanding etiologic causes of spontaneous preterm delivery, but, before suggesting this as a course of action, low levels of prohepcidin in patients with PTL need to be more fully investigated.

No abstract