Phytochemical investigation of the seeds of Capsella bursa-pastoris led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide (1) and 11-methylsulfinyl-undecanamide (2), along with two known compounds (3−4), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analyzing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds 1−4 were evaluated for their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 1−4 exhibited potential anti-inflammatory activities on NO release characterized by decreasing the mRNA expression levels of inducible NO synthase (iNOS), cytokines cyclooxygenase-2 (COX-2), and interleukin 6 (IL-6).

A new oleanane-type triterpene from Ardisia lindleyana D.Dietr and its cytotoxic activity Abstract：A new oleanane-type triterpene, ardisiapunine A (1), together with eight known compounds were isolated from the roots of Ardisia lindleyana D.Dietr. Their chemical structures were determined by means of spectroscopic methods including HR-ESI-MS and (1D, 2D) NMR data. The absolute configuration of compound 1 was established by a single-crystal X-ray diffraction experiment. The new compound is an unusual oleanane-type triterpene bearing an acetal and a C-13-C-18 double bond. The cytotoxicity of all isolated compounds were evaluated using four human cancer cell lines, including A549, HepG2, HeLa and U87. The new compound 1 and compound 2 were weakly active but the known compound 6 exhibited a high cytotoxicity compared to cisplatin.

One new pentacyclic triterpenoid saponin, ardisiapunine E (1), along with two known compounds were isolated from the root of Ardisia lindleyana D.Dietr. Their structures were elucidated by 1H and 13C NMR, DEPT, HMBC, HSQC, 1H-1H COSY and NOESY spectroscopic analyses, ESI-MS, and literature. Compounds 1-3 exhibited obvious anti-proliferative activities against HeLa cell line in a dose- and time-dependent manner through inducing G2/M phase arrest and apoptosis in vitro, both consisting of pentacyclic triterpenes and sugar. Hence, this study identified a new and two known pentacyclic triterpenoid saponin promoting apoptosis as a potential therapeutic option for cancer.

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