Ferroelectric nanostructures are attracting tremendous interest because they offer a promising route to novel integrated electronic devices such as non-volatile memories and probe-based mass data storage. Here, we demonstrate that high-density arrays of nanostructures of a ferroelectric polymer can be easily fabricated by a simple nano-embossing protocol, with integration densities larger than 33 Gbits inch(-2). The orientation of the polarization axis, about which the dipole moment rotates, is simultaneously aligned in plane over the whole patterned region. Internal structural defects are significantly eliminated in the nanostructures. The improved crystal orientation and quality enable well-defined uniform switching behaviour from cell to cell. Each nanocell shows a narrow and almost ideal square-shaped hysteresis curve, with low energy losses and a coercive field of approximately 10 MV m(-1), well below previously reported bulk values. These results pave the way to the fabrication of soft plastic memories compatible with all-organic electronics and low-power information technology.
We set out to determine whether a minimally invasive approach for one-level instrumented posterior lumbar interbody fusion reduced undesirable changes in the multifidus muscle, compared to a conventional open approach. We also investigated associations between muscle injury during surgery (creatinine kinase levels), clinical outcome and changes in the multifidus at followup. We studied 59 patients treated by one team of surgeons at a single institution (minimally invasive approach in 28 and conventional open approach in 31, voluntarily chosen by patients). More than 1 year postoperatively, all the patients were followed up with the visual analogue scale (VAS) and Oswestry disability index (ODI), and 16 patients from each group were evaluated using MRI. This enabled the cross-sectional area (CSA) of lean multifidus muscle, and the T2 signal intensity ratio of multifidus to psoas muscle, to be compared at the operative and adjacent levels. The minimally invasive group had less postoperative back pain (P \ 0.001) and lower postoperative ODI scores (P = 0.001). Multifidus atrophy was less in the minimally invasive group (P \ 0.001), with mean reductions in CSA of 12.2% at the operative and 8.5% at the adjacent levels, compared to 36.8% and 29.3% in the conventional open group. The increase in the multifidus:psoas T2 signal intensity ratio was similarly less marked in the minimally invasive group where values increased by 10.6% at the operative and 8.3% at the adjacent levels, compared to 34.4 and 22.7% in the conventional open group (P \ 0.001). These changes in multifidus CSA and T2 signal intensity ratio were significantly correlated with postoperative creatinine kinase levels, VAS scores and ODI scores (P \ 0.01). The minimally invasive approach caused less change in multifidus, less postoperative back pain and functional disability than conventional open approach. Muscle damage during surgery was significantly correlated with long-term multifidus muscle atrophy and fatty infiltration. Furthermore these degenerative changes of multifidus were also significantly correlated with long-term clinical outcome.
Polymer crystallization is notoriously difficult to control. Here, we demonstrate that the orientation of polymer crystals can be fully controlled at the nanoscale by using nanoimprint lithography (NIL) with molds bearing nanotrenches to shape thin films of poly(vinylidene fluoride). This unprecedented control is due to the thermomechanical history experienced by the polymer during embossing, to the shift of the nucleation mechanism from heterogeneous to homogeneous in confined regions of the mold, and to the constraining of the fast growth axis along the direction of the trenches. NIL thus appears as an ideal tool to realize smart polymer surfaces where crystal ordering can be tuned locally.
Nanopatterned brushes of a thermo-responsive polymer, poly(2-(2-methoxyethoxy)ethyl methacrylate) (PMEO2MA), displaying a collapse temperature in the physiological range were synthesized for grafting diameters from a few micrometers down to 35 nm. The reversible collapse transition of the nanobrushes was studied in water as a function of their lateral confinement, down to ensembles of brushes containing only approximately 300 chains. The confinement results in a considerable broadening of the collapse transition and in an increase of the degree of vertical swelling, which can be explained by the internal structure of the nanodroplets derived from a theoretical model of dry nanobrushes. These results enable the rational design of responsive surfaces having a tunable topography engineered at the nanometer scale, which is of direct interest for the development of soft nanoactuators and new substrates for cell adhesion studies.
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