Purpose Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education.Methods This case-control study was performed on 107 children aged 2–14 years, 56 children with subclinical hypothyroidism in the case group, and 51 healthy children in the control group presenting to Ayatollah Mousavi Hospital in Zanjan and private clinics of Zanjan city. Thyroid stimulating hormone, triiodothyronine, thyroxine, creatinine, and uric acid were measured in both groups of children after obtaining the necessary criteria for entering the study.Results Compared to the control group, subjects with subclinical hypothyroidism had higher levels of creatinine (P=0.003), while serum uric acid levels in subclinical hypothyroid children was not significantly different from those in the control group (P=0.200).Conclusions In subclinical hypothyroidism in children, creatinine was higher than in euthyroid patients, but uric acid was not different.

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Aim of the study: An inverse correlation between excessive body weight and response to cholecalciferol in vitamin D deficiency (VDD) has been reported but no adjusted or conventional dose and treatment period has universally been recommended by the paediatric guidelines for obese children. In this study, we explored the efficacy of vitamin D supplementation in treatment of children with VDD based on their body mass index (BMI) and different levels of initial serum 25(OH)D. Material and methods: In a single-centre, prospective, open label non-randomized trial in 255 subjects, baseline serum 25(OH)D was measured and different doses of oral D3 prescribed accordingly. Serum D 3 was measured at the end of the treatment period. All statistical analyses were conducted using the statistical package SPSS and p values less than 0.05 considered statistically significant. Results: The response rate to vitamin D supplementation was associated with the patients' BMI characteristics. 25(OH)D levels normalized in 97.7% and 92.7% of the non-obese and obese subjects, respectively. In subjects with BMI ≥ 85 th percentile, there was a lower increase in vitamin D levels after treatment than those with a BMI < 85 th percentile. Evaluating the efficacy of the therapeutic dosage of cholecalciferol as per different categories of vitamin D levels, we observed the highest increase in the level of serum D 3 in the severely deficient D 3 category of both obese and non-obese groups. Conclusions: There is an inverse correlation between high Body Mass Index and response to treatment with vitamin D supplementation, suggesting a higher dose of vitamin D for the optimal treatment of vitamin D deficiency in obese children.