No abstract

Suppression of tissue inhibitor of matrix metalloproteinase (TIMP) is associated with the tumor-like invasion of fibroblast-like synoviocytes (FLSs) that occurs during rheumatoid arthritis-related cartilage destruction. Silent information regulator 2 homolog1 (SIRT1), a histone deacetylase, is widely involved in transcriptional regulation, genomic stability, metabolism and DNA repair. Recent studies suggest that SIRT1 may also impact inflammatory response and the proliferation of FLSs in rheumatoid arthritis (RA). However, it is unknown whether SIRT1 has a role in the tumor-like invasion of FLSs in rheumatoid arthritis. Herein we report that SIRT1 contributes to FLS invasion and cartilage destruction via a TIMP1-dependent mechanism. Elevated SIRT1 in RA synovia suppresses TIMP1 expression via deacetylation of TIMP1-associated histones, thereby disrupting the binding of the transcription factor specificity protein 1 (Sp1) to the TIMP1 promoter. In rats with collagen-induced arthritis, depletion of SIRT1 remarkably promoted TIMP1 expression in synovial tissues and ameliorated cartilage destruction. These results describe a new role for SIRT1 and demonstrate its potential value as a therapeutic target for rheumatoid arthritis.

With the rapid development of the economy and technology, intelligent wearable devices have gradually entered public life. Flexible sensors, as the main component of wearable devices, have been widely concerned. However, traditional flexible sensors need an external power supply, lacking flexibility and sustainable power supply. In this study, structured poly­(vinylidene fluoride) (PVDF)-based composite nanofiber membranes doped with different mass fractions of MXene and zinc oxide (ZnO) were prepared by electrospinning and were then assembled to flexible self-powered friction piezoelectric sensors. The addition of MXene and ZnO endowed PVDF nanofiber membranes with better piezoelectric properties. The structured PVDF/MXene-PVDF/ZnO (PM/PZ) nanofiber membranes with a double-layer structure, interpenetrating structure, or core–shell structure could further enhance the piezoelectric properties of PVDF-based nanofiber membranes through the synergistic effects of filler doping and structural design. In particular, the output voltage of the self-powered friction piezoelectric sensor made of a core–shell PM/PZ nanofiber membrane showed a good linear relationship with the applied pressure and could produce a good piezoelectric response to the bending deformation caused by human motion.

In the past decades, the rapid development of the Internet of Things (IoT) technology and artificial intelligence (AI) has driven the research boom of physical sensors. Material selection, structure design, and performance research for physical sensors have attracted extensive attention from worldwide researchers in the field of advanced manufacturing. Significant technological progress has been made in the area of physical sensors for applications in various fields such as electronic skin, biomedicine, and tissue engineering. There are many methods (e.g., electrospinning, screen printing, or rotary coating) to prepare physical sensors. Among them, nanofibers or nanofiber membranes prepared by electrospinning have the advantages of a nanosize effect, high specific surface area, and high porosity over other reported materials used for physical sensors. In this review, the working principles of various physical sensors including pressure sensors, strain sensors, temperature sensors, and humidity sensors are first introduced; recent research progress of electrospun nanofiber-based physical sensors is then summarized. Finally, future research trends and associated challenges of large-scale adoption of electrospun physical sensors are proposed.