Istihalah and istihlak are not an extraterrestrial subject and have been debated over centuries among shariah scholars. Halal Pharmaceutical had been clearly explained that must comply with shariah prerequisite to be endorsed as halal compliance medicine. However, this industry often faces unmatched medicine which able to heal deteriorated diseases such as thrombosis or embolism that require second opinion by Shariah scholars. The medicine named Low Molecular Weight Heparin (LMWH) had been imposed the fatwa on it by Malaysian National Fatwa Council (MNFC), however, some exempted conditions require this porcine base medicine for prophylaxis or therapy. This paper aims to propose istihalah and istihlak to be legal indicators through fiqh methods in the making of fatwa regarding to this notorious medicine. This paper employs qualitative methodology which using documents review method to analysis the data.