AbstrakPasien dengan penurunan kesadaran masih tinggi angka kejadiannya. Salah satu terapi untuk menangani pasien dengan penurunan kesadaran adalah dengan pemberian stimulasi Al-Quran. Tujuan penelitian mengetahui pengaruh stimulasi Al-Quran terhadap Glasgow Coma Scale pasien dengan penurunan kesadaran diruang Intensive Care Unit (ICU). Jenis penelitian Pre Experiment dengan one grup pre-post test design. Populasi adalah pasien dengan penurunan kesadaran sebanyak 14 pasien. Sampel berjumlah 10 pasien dengan teknik non probability sampling jenis accidental sampling. Data dikumpul melalui observasi, pengukuran Glasgow Coma Scale sebelum dan sesudah intervensi. Dianalisis dengan uji T berpasangan. Hasil penelitian menunjukkan terdapat peningkatan nilai Glasgow Coma Scale antara sebelum dan setelah pemberian stimulasi Al-Quran dengan hasil uji komputerisasi T Berpasangan didapatkan nilai P value = 0,003 yang lebih kecil dari ? = 0,05. Kesimpulan dari penelitian ini terdapat pengaruh stimulasi Al-Quran terhadap Glasgow Coma Scale pasien dengan penurunan kesadaran di ruang Intensive Care Unit (ICU).

Banjir merupakan salah satu bencana yang sering terjadi di Gorontalo. Pada tahun 2013-2016 Gorontalo mengalami 56 kejadian bencana banjir. Penelitian ini bertujuan untuk menganalisis pengaruh penyuluhan terhadap tingkat pengetahuan masyarakat menghadapi bencana banjir di Desa Permata Kabupaten Boalemo Provinsi Gorontalo. Jenis penelitian yang digunakan dalam penelitian ini adalah Pre-Experimental design dengan jenis rancangan One Group Pretest-posttest design. Populasi dalam penelitian ini sebanyak 140 orang kepala keluarga, sampel sebanyak 30 orang dan pengambilan sampel menggunakan cara non probability sampling jenis purposive sampling. Teknik analisa data menggunakan uji wilcoxon. Hasil penelitian menunjukkan bahwa sebelum diberikan penyuluhan, tingkat pengetahuan masyarakat dikategorikan cukup (54,12%), setelah diberikan penyuluhan, tingkat pengetahuan masyarakat dikategorikan baik (77,51%), dan setelah dilakukan uji wilcoxon di peroleh hasil nilai z -4.839 dan nilai p-value =0,000 (α 0.05). Dapat disimpulkan bahwa terdapat pengaruh penyuluhan terhadap tingkat pengetahuan masyarakat di Desa Permata Kabupaten Boalemo Provinsi Gorontalo. Diharapkan lebih meningkatkan kerja sama antara dinas kesehatan dengan badan penanggulangan bencana daerah dalam melakukan sosialisasi kepada masyarkat tentang kesiapsiagaan bencana banjir.

Penelitian ini bertujuan untuk mengetahui gambaran kondisi kesehatan mental Masyarakat akibat COVID-19 pasca bencana gempa di Kabupaten Mamuju Sulawesi Barat. Desain Penelitian yang digunakan dalam penelitian ini adalah metode penelitian survei deskriptif. Populasi adalah Masyarakat yang terdampak bencana gempa di kabupaten Mamuju Sulawesi Barat, dan teknik pengambilan sampel secara Accidental sampling dengan total sampel sebanyak 178 responden. Pengumpulan data berdasarkan kuisioner MHI, yang dikumpulkan melalui google form dan observasi langsung di lapangan. Analisa data dilakukan dengan distribusi frekwensi. Hasil Penelitian didapatkan bahwa Kondisi Mental Masyarakat akibat Covid-9 pasca bencana gempa di Kabupaten Mamuju Sulawesi Barat, dalam kondisi kesejahteraan psikologis sebanyak 88,3 %, kondisi tekanan psikologis sebanyak 11,3 %, kesimpulannya bahwa Kondisi Mental Masyarakat akibat Covid 19 pasca bencana gempa di Kabupaten Mamuju Sulawesis Barat dalam kondisi kesejahteraan psikologis.

In the urogenital system, simvastatin is associated with interstitial cystitis adverse effects, but the exact mechanism is not yet clearly defined. This study aims to determine the effect of simvastatin on eosinophilic inflammation of bladder tissue in vivo. Laboratory experimental research design with the post-test only control group using 24 female Wistar rats aged 8-10 weeks were randomly divided into simvastatin 50mg/kg BW (n=12) or placebo carboxymethylcellulose 0.5% (n=12). All groups received treatment through oral gavage for thirty days. After that, each group was divided equally into three subgroups: control rat, day 0 Interstitial Cystitis (IC) rat (IC0), and day 3 IC rat (IC3). Control or IC0 rats each received intravesical instillation of buffered saline or protamine sulfate (PS), respectively, and were terminated immediately less than 3 hours after instillation. The IC3 rats received intravesical PS instillation and were terminated three days post-instillation. The bladder tissue was made in Hematoxylin-Eosin histology preparations. As in previous studies, the results showed successful desquamation of the urothelium after PS instillation. Tissue eosinophil counts were significantly higher in the simvastatin group than in the placebo group in the IC3 model (15.50±5.92 vs. 4.00±2.83, p=0.013). It can be concluded that the mechanism of the adverse effect of simvastatin on bladder tissue is through increased tissue inflammation mediated by eosinophils along with urothelial layer destruction by the protamine sulfate.

Background and context: Advancement in science and technology has been appropriately applied in the prevention of cervical cancer that it is not unreasonable to conclude that cervical cancer is potentially an eradicable disease. While there is significant reduction in both incidence and mortality from cervical cancer in developed countries that have instituted organized cervical cancer prevention programs, the incidence and mortality from cervical cancer in developing countries are either static or on the rise. This has been reported to be largely due to lack of organized cervical cancer screening program in developing countries despite the availability of effective screening methods appropriate for low resource settings. The challenges of planning a sustainable comprehensive cervical cancer control program in low resource settings are hereby highlighted based on experience from execution of Global Scholar's seed grant of American Cancer Society. Aim: To document innovative approach to overcoming challenges of planning a comprehensive cervical cancer care and control in low resource settings. Strategy/Tactics: The strategy recommended by Alliance for Cervical Cancer Prevention in Planning and Implementing Cervical Cancer Control Program: A guide for manager was adopted in planning of a comprehensive cervical cancer prevention program for Kebbi state. Program/Policy process: Learning from HIV program implementation, the program adopted policy of integration into existing health structure rather than creating a vertical program. Conscious effort was being made at every stage not to create impression of a special intervention program deserving extra pay for the healthcare professionals nor incentives other than good health for the clients. Outcomes: A local guideline was developed based on a trade-off consideration of evidence of efficacy, cost-effectiveness and sustainability within the context of prevailing local challenges. What was learned: Literature on cervical cancer prevention seems to be skewed in favor of search for appropriate screening method for low resource settings rather than programmability of cervical cancer prevention and control strategies. No individual component of cervical cancer prevention will impact on the burden of cervical cancer independent of the other components. For a cervical cancer program to be impactful, all the components; awareness creation, acceptable screening method, treatment and follow-up of screen positive women, call and recall of clients, treatment of invasive lesions must not only all be available (albeit at different levels of sophistications) but must also be linked. Rapidly evolving science ironically could pose a significant challenge to sustainable execution of a comprehensive cervical cancer prevention program in low resource settings if there is no guideline to guide interfacing of program with evolving science.