Ростовский государственный медицинский университет, Ростов-на-Дону, Россия chronic ischemic disease of The digesTiVe sYsTem: diagnosTic proBlems and iTs soluTions Bogatirev V. g., marinchuk a. T., gasanov m. Z., Terentyev V. p., Tkachev a. V. rostov state medical university, rostov-on-don, russia Хроническая ишемическая болезнь органов пищеварения (ХИБОП)-редкое заболевание, которое проявляется появлением абдоминальных болей после еды и потерей массы тела. Ввиду неспецифичности жалоб, отсутствия патогномоничных признаков при объективном обследовании, недостаточной настороженности врачей верификация болезни представляется сложной, и зачастую ХИБОП является диагнозом исключения. Вместе с тем оценка факторов риска (возраст пациента, высокая степень коморбидности, факторы риска атеросклероза, наличие васкулопатий в бассейнах нескольких артерий и др.) наряду с инструментальным обследованием, включающим триплексное УЗИ, ангиографию, МРТ, КТ-ангиографию, тонометрию, может существенно повысить выявление ХИБОП. Представлен актуальный взгляд на проблему с обзором современной литературы, а также клинический разбор пациента с хронической абдоминальной ишемией, длительно наблюдавшегося по поводу патологии желудочно-кишечного тракта неишемического генеза. Ключевые слова: хроническая ишемическая болезнь органов пищеварения, стентирование, окклюзия верхней брыжеечной артерии Chronic ischemic disease of the digestive system (СIDDS) is a rare pathology which is manifested by the abdominal pain after meals and weight loss. In view of the non-specific nature of complaints, the absence of pathognomonic signs in an objective examination, the lack of alertness of doctors, the verification is complex, and often СIDDS is the diagnosis of exclusion. However, an assessment of the risk factors (patient age, high degree of comorbidity, atherosclerosis risk factors, the presence of vasculopathies in several arterial basins) along with the proper instrumental examination, including triplex ultrasound, angiography, MRI, CT angiography, tonometry can significantly improve the identification of СIDDS. This article presents a modern approach to the problem of СIDDS with the review of the current literature, as well as a clinical case of the patient with chronic abdominal ischemia, which has been observed for a long time for the gastrointestinal tract pathology of non-ischemic origin.

Objective: The objective of this work was to carry out studies in the field of development of a hydroalcoholic extract from the liquorice root that has a high level of antimicrobial activity.Methods: For the antibacterial study of extracts, we have used the agar well diffusion method. In our research, we have utilized six test-strain microorganisms: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Proteus vulgaris ATCC 4636, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653, and Bacillus subtilis ATCC 6633. Authors have applied vector theory for antimicrobial activity comparison of liquorice root extracts.Results: Phytochemical composition and antimicrobial activity of hydroalcoholic extracts from the liquorice root with the use of different concentrations of ethanol have been studied. The optimal range of ethanol concentration of 65±15% v/v has been found. The dependency between the integral index of antimicrobial activity of the extract and concentration of glycyram and licuroside has been found. The minimal concentration of glycyram and licuroside in the extract has been calculated for an exhibition of the target level of extract’s antimicrobial activity, which is 1.0 and 0.11% w/v, respectively.Conclusion: It has been found that the concentration of licuroside has greater influence on the integral index of extract’s antimicrobial activity in comparison with that one of glycyram. A highly effective technology for obtaining an extract with target phytochemical parameters has been suggested.

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