Aim. To study serum content of a number of known adipokines, myokines and cytokines and compare obtained data with overweight phenotype and characteristics of tumor in untreated patients with endometrial cancer (EC) Materials and methods. The study included 88 patients with a mean age 60.080.67 years and a mean body mass index (BMI) 32.900.83. Patients were subjected to anthropometry and analysis of laboratory parameters, including serum level of leptin, adiponectin, omentin, prefilin (Pref-1), myostatin, irisin, IL-6 as well as insulinemia and insulin resistance index (HOMA-IR). On the basis of combination of anthropometric and laboratory data patients with overweight (BMI 25.0) were subdivided into the groups with "standard" (S) and conditionally "metabolically healthy" (MH) phenotype. Results. Levels of leptin, insulin and adiponectin in the serum of patients with EC are associated with BMI value and demonstrate significant differences between S and MH groups. Levels of prefilin, myostatin, and IL-6 are not associated with an increase in BMI, but are also different in patients with S and MH phenotype of overweight.For levels oа irisin, omentin, and TNF-alphathere is no peculiar dependence both, the BMI, and of belonging to a group with S or MH phenotype. Omentin level in the serum is associated with less favorable tumor differentiation (MH group), while IL-6 level with a more advanced stage of the tumor (all patients and group S). Conclusion. Adipokines, myokines and cytokines circulating in blood of EC patients vary in their connections with BMI or with "standard" or "metabolically healthy" phenotype of its excess. They vary also in relation to EC features, which in sum may have practical importance.

■ Ключевые слова: рак эндометрия; гормонально-метаболический статус; сравнительная динамическая оценка. ■ Keywords: endometrial cancer; hormonal and metabolic status; a comparative dynamic evaluation. COMPARATIVE EVALUATION OF HORMONAL-METABOLIC STATUS OF ENDOMETRIAL CANCER PATIENT´S OVER THE PAST FIVE DECADES

No abstract

Vladimir Dilman ? an internationally renowned endocrinologist, oncologist, and gerontologist whose name is firmly entrenched into the history of medical science. The eve of his 90th birth anniversary is a particularly appropriate time to remember the achievements of Vladimir Dilman. Prof. Dilman predicted what has become a cornerstone of modern theories of origin of many chronic age-associated diseases, highlighting the role of the increase of hypothalamic sensitivity to the inhibitory action of peripheral hormones in the development of main non-communicable diseases. The appreciation of the principal works of V. M. Dilman and his scientific biography not only increases our understanding of this subject, but provides a stimulus to independent research by younger generations and experienced specialists in the field of me. dical science and . practice, including e. ndocrinology and diabetology.