ГОУ ВПО Владивостокский государственный медицинский университет Росздрава, г. Владивосток Резюме. В последние годы вопросы патогенеза различных инфекционных болезней рассматриваются с позиций клинической иммунологии. Изучение механизмов патогенеза острых и хронических вирусных инфекций на примере геморрагической лихорадки с почечным синдромом и хронического вирусного гепатита С показывает иммуноопосредованность развития инфекционного процесса. Дисбаланс системного и локального цитокинового статуса характеризует прямое влияние иммунной системы на функцию всех органов и систем макроорганизма, определяет тяжесть, течение и прогноз заболевания.

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For the period 1967-1996 he was observed 368 patients in the age 16-65 years with levelnum paragonimiasis with disease duration from 1-2 to more than 10 years. 248 patients had acute paragonimiasis with disease duration up to 1 year, 20 – subacute (duration of illness over 1 year), and 100 – chronic disease (proceeded more than 2 years). The disease is characterized by fever, cough, chest pain, focal and infiltrative darkening in the lungs, cystic formations, exudative pleurisy, spontaneous pneumothorax, leukocytosis and eosinophilia in peripheral blood. The diagnosis was confirmed in 97.9% of cases by serological method. Recovery was achieved in 89% of patient’s levelnum paragonimiasis (PL) when using praziquantel.

Results of the analysis of cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant females recorded in the Primorsky Krai, clinical symptomatology of the disease, pregnancy outcome and neonatal state are presented. In case of mild course of HFRS a favorable outcome of the disease, which had not broken a normal course of pregnancy without consequences for the child was observed. Severe course of HFRS in pregnant females led to premature labors and subsequent death of a premature infant. Serologic examinations indirectly confirmed the absence of transplacental transmission of the virus from the mother.

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