EEG recording was performed in healthy women during various phases of menstrual cycle. Comparative study showed that the power spectrum of EEG α-waves in central and mediotemporal areas significantly decreases during ovulation. In the menstrual phase coherent characteristics of EEG α-waves increased in symmetrical occipital and intrahemispheric parieto-occipital areas.Institute of Obstetrics and Pediatrics, Rostov on Don. Address for corre spondence: v.vasiljeva@rniiap.ru. V. V. Vasil'eva Reproductive function is regulated by CNS (up to the higher part of CNS). Study of spontaneous electrogenesis should elucidate the neurophysiological mechanisms for integration of the cortical-hypothalamicpituitary-ovary system. Previous studies showed that some parameters of spontaneous and evoked brain activity vary during menstrual cycle in parallel with changes in hormonal status [2][3][4][5][6][7][8][9]. There are contradictory data on the type of these variations. It should be emphasized that studies of the central mechanisms of normal menstrual cycle do not take into account asymmetry of the female reproductive system. This system is characterized by lateralization of generative function in the ovaries. Despite the existence of paired ovaries and occurrence of multiple ovulation in each ovary, only one follicle in one of the ovaries usually undergoes maturation and ovulation over menstrual cycle. Published data demonstrate significant morphological and functional differences between the ovaries and predominance of the right ovary [1].Here we studied spectral and coherent characteristics of EEG during various phases of normal menstrual cycle in conventionally healthy women of reproductive age. MATERIALS AND METHODSThirty-five women of 18-38 years were examined in various phases of menstrual cycle. The study was performed at the beginning of the menstrual cycle (day 2-3 of menstruation) and on the day of ovulation (as confirmed by the results of ultrasonography and measurement of rectal temperature). The anamnesis showed that these women were healthy and had regular menstrual cycle. Examination included ultrasound study of the size and location of the dominant follicle and EEG recording.Recording and spectral-and-coherent study of EEG were performed using an Encephalan 131-01 hardware-software complex. Total bioelectric activity of the brain was recorded unipolarly in 16 leads according to the 10-20 system. Recording was conducted in symmetrical frontal, temporal, central, parietal, and occipital cortical areas (Fp1-Fp2, F3-F4, F7-F8, T3-T4, T5-T6, C3-C4, P3-P4, and O1-O2). The reference electrode was placed on earlobes.During the first examination we recorded general and expanded EEG to perform a clinical study and estimate pathological features of brain activity. This approach is particularly important for subjects with neurological disorders.Data visualization and selection of five 5-second EEG epochs without non-brain artifacts involved an application software package. For selected epochs the
Изменение характера экспрессии биоактивных пептидов способствует формированию многих осложнений гестации. Целью исследования явилось изучение влияния половой принадлежности плода на продукцию ангиогенных факторов и цитокинов у женщин при физиологической и осложненной беременности. У 172 женщин с физиологической беременностью и 188-с плацентарной недостаточностью определяли уровень ангиогенных факторов и цитокинов в венозной крови беременных с учетом пола вынашиваемого плода. Обнаружено, что у беременных девочками независимо от характера течения беременности отмечались более высокие уровни сосудисто-эндотелиальных факторов и цитокинов. Выявленная динамика биоактивных полипептидов указывает на существование специфики сигналов со стороны маточно-плацентарно-плодового комплекса материнскому организму, которые статистически значимо связаны с полом вынашиваемого плода и свидетельствуют о более выраженной заинтересованности иммунной системы в ответе материнского организма на гестационные изменения. Указанные изменения более характерны для беременных с девочками. Ключевые слова: физиологическая беременность, плацентарная недостаточность, пол плода, биоактивные полипептиды Changes in the expression of bioactive peptides contribute to the formation of many complications of gestation. The aim of the research was to study the effect of fetal sex on the production of angiogenic factors and cytokines in women during physiological and complicated pregnancy. In 172 women with physiological pregnancies and 188 with placental insufficiency, the level of angiogenic factors and cytokines in the venous blood of pregnant women was determined taking into account the sex of the fetus. It was found that in pregnant women with female fetuses, regardless of the nature of the course of pregnancy-physiological or complicated, higher levels of vascular endothelial factors and cytokines were noted. The identified dynamics of bioactive polypeptides indicates the existence of specific signals from the utero-placental-fetal complex to the maternal organism, which are statistically significantly related to the sex of the fetus and indicate a more pronounced interest of the immune system in the response of the maternal organism to gestational changes. These changes are more characteristic for pregnant women with female fetuses.
We studied the effect of intermittent hypobaric hypoxia on morphofunctional characteristics of the thyroid gland during experimental hypothyroidism. Functional activity of the thyroid gland increased in the early period of hypoxia. Morphofunctional parameters reached a constant level with increasing the duration of hypoxia to 7-15 days. A new functional level was characterized by increased activity and normal function of glandular cells.
Преэклампсия (ПЭ) остается важнейшей медико-социальной проблемой, являясь, согласно данным ВОЗ, причиной перинатальной заболеваемости и смертности новорожденных а также 30% случаев материнских смертей [1-4]. Несмотря на значительное число исследований, не существует единой классификации ПЭ как по факторам, способствующим ее развитию, так и по времени клинической манифестации. В отечественной литературе принято различать раннюю ПЭ, развивающуюся при сроке беременности до 34 нед, и позднюю-после 34 нед [2]. В зарубежной литературе предлагается другая классификация: преждевременная ПЭ (preterm-preeclampsia), развивающаяся при сроке беременности до 32 нед либо в период от 32 до 37 нед, а также ПЭ (term-preeclampsia), развивающаяся после 37 нед [5]. Большинство классификаций ПЭ в качестве факторов риска учитывают уровень протеинурии, артери
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