The review of the publications devoted to the methods of early diagnosing autism spectrum disorders (ASD) among children. The spread of this pathology causes mixed assessments in scientific community. The frequency of ASD in different countries makes up from 5 to 90 among 10,000 children and teenagers. An increase in morbidity makes the problem of diagnosing ASD among children very urgent. The main method of diagnosing is behavioral, but they allow to diagnose autism when the child is older than 1.5 years old, when medical and corrective actions are no longer effective. The prenatal diagnostics of the ASD are almost unused. The methods of genetic analysis are considered to be additional and don’t have the direct diagnostic meaning connected with the lack of clear understanding of the etiology and pathogenesis of ASD. According to Russian medical regulations children having early signs of autism can’t be defined in the age when timely medical treatment is effective. Due to this fact it was concluded that it is necessary to develop screening methods and regulations of providing medical treatment to children an teenagers having ASD.

The purpose of this studyis to evaluate the ability of L-tryptophan used in complex therapy of delayed psycho-speech development in children to influence the dynamics of cognitive performance.Materials and methods. The study included 80 children aged 3–7 years with delayed psycho-speech development (DPSD). The main group consisted of 37 children (25 male and 12 female), a control group – 43 patients (30 male and 13 female). Both groups of children were comparable in age, sex, degree of speech and cognitive impairment, and IQ level. Patients in the main group have taken standard therapy with L-tryptophan (25–50 mg per day depending on the age) supplement for 14 days. Control patients have taken standard therapy only. Psychodiagnostic tests at the entrance and exit of patients from this study was carried out for evaluation the dynamics of cognitive functions. All differences were considered significant at p < 0.05.Results. The study suggests that oral L-tryptophan intake selectively affects the dynamics of cognitive performance in children with DPSD. So, we studied pre- and post-treatment cognitive performance in both group patients and noted a significant improvement in the visual memory (p < 0.001) and an increase in thinking productivity (p < 0.001) in the tryptophan group versus similar indicators in the control group. Intergroup differences (p < 0.001 and p = 0.026, respectively, for the main and control groups) also found.Conclusion. Two-week L-tryptophan intake in complex therapy of DPSD in children can significantly improve the cognitive activity, and greatly increase both the effectiveness and sustainability of treatment outcomes, which will significantly reduce the time and frequency of hospitalization and financial costs for the rehabilitation of this patients.

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ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека» (664003, г. Иркутск, ул. Тимирязева, 16, Россия) Обоснование. Противоречивость данных в отношении психологического профиля подростков с эссенциальной артериальной гипертензией (ЭАГ) как одного из важнейших факторов этиопатогенеза данного заболевания обуславливает актуальность поиска взаимосвязи психологических черт с особенностями циркадной организации артериального давления (АД). Целью данного исследования явилось изучение ассоциации эмоционально-личностных особенностей с параметрами суточного мониторирования АД (СМАД) у подростков с ЭАГ. Методы. На базе клиники ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека» обследовано 110 европеоидов мужского пола в возрасте 14-17 лет (средний возраст 15,92 ± 1,12 года) с диагнозом ЭАГ. Проведено психологическое тестирование и СМАД. Результаты. Определено несколько наиболее значимых психологических черт, ассоциированных с разными параметрами СМАД и стабилизацией АГ. Повышенная гипертимность, проявляющаяся в повышенной активности, раздражительности, гневливости и несговорчивости, ассоциирована со стабилизацией ЭАГ у подростков. Умение выражать свои эмоции вербально или физически (в том числе конструктивным способом) защищает сердечно-сосудистую систему от чрезмерных колебаний уровня АД в ночное время. Психологический профиль с ведущим паттерном подавления тревожно-агрессивного аффекта (раздражение, обида, тревожность, интроверсия) главным образом пагубно влияют на время гипертензии АД и среднесуточный уровень АД. Заключение. Подросткам с ЭАГ, имеющим определенные эмоционально-личностные особенности, необходимо дифференцировано проводить психотерапевтические вмешательства для ранней профилактики осложнений нарушений циркадной организации сердечно-сосудистой деятельности. Ключевые слова: подростки, эссенциальная артериальная гипертензия, суточное мониторирование артериального давления, психология, эмоции PSYCHOLOGICAL FEATURES OF ADOLESCENTS WITH ESSENTIAL HYPERTENSION Kosovtseva A.S., Kolesnikova L.I., Rychkova L.V., Polyakov V.M., Bairova T.A. Scientific Сentre for Family Health and Human Reproduction Problems (ul. Timiryazeva 16, Irkutsk 664003, Russian Federation) Background. The inconsistency of data about psychological profile of adolescents with essential arterial hypertension (EH), as one of the most important factor in the pathogenesis of this disease, causes the relevance of searching the relationship between psychological traits and features of the circadian blood pressure (BP).organization. The aim of this study was to study the association between personality characteristics and parameters of 24-hour blood pressure monitoring in adolescents with EH. Materials and methods. We carried out an investigation of 14-17 year old (15.92 ± 1.12) Caucasian male patients with EAH (n = 110) in clinic Scientific Сentre for Family Health and Human Reproduction Problems. Psychological testing and ambulatory blood pressure monitoring (ABPM) have been carried. Results. In our study were determined...