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The aim of this research is to determine the characteristics of endothelial factors and the hemostatic system conditions with malignant neoplasms patients, which were exposed to ionizing radiation. Total number of examined people is 223, 153 of them are patients with gastrointestinal tract oncopathology. The article presents the results of the analysis of numerical indicators of endothelial condition and platelet hemostasis of patients, who had cancer. They lived in the regions of Kazakhstan, subjected to contamination of radionuclides as a result of nuclear weapons tests, which took place in this region from 1949 to 1989. These results then were compared to cancer patients and healthy individuals with no radiation risk. The study revealed the presence of higher levels of endothelial dysfunction and following trigger of the hemostatic system in patients with malignant tumors of the gastrointestinal tract. In particular, the defined high degree of endothelial dysfunction include endotheliumdependent vasodilation, content desquamated endothelial cells in peripheral blood and von Willebrand factor. These indicators have a clear correlation with the degree of disorder of studied parameters of the hemostasis, which can cause the development of thrombotic complications.

Aim: To evaluate the effects of body mass index on fundal height charts. Methods: Design: Cross-sectional study. The study complies with the principles of the Helsinki Declaration. Approved by the Ethics Committee of The Semey State Medical University protocol No.2 of 14.11.2014.Study was conducted in Semey and in the region within January-December, 2014. We identified 2387 cases of uncomplicated pregnancy ended in childbirth of full-term fetus in cephalic presentation, with a weight between 2,500 and 4,000 grams. Depending on the body mass index, the cases were divided into 3 groups. The first group included pregnant women with a body mass index of less than 18.5. The second group included cases with body mass index of 18.5-24.9. while the third group included pregnant women with an index greater than 24, which corresponds to overweight and obesity.Statistical analysis was performed with SPSS package, version 20. We used descriptive statistics and nonparametric tests for unpaired samples (Kruskal Wallis and Mann-Whitney).Results: Statistically significant differences were identified between the average fundal height indexes in all stages of gestation (p = 0.001), except for 22 weeks (p = 0347) and 28 weeks (p = 0.14). Pairwise comparisons with MannWhitney test between "deficit weight -normal weight" and "deficit weightoverweight, obesity" and "normal weight -overweight, obesity" groups showed no statistically significant difference in fundal height of pregnant women with underweight and normal weight at pregnancy terms of 24, 25, 34, and 35 weeks. At 26 and 31 weeks of pregnancy there were no statistically significant difference in pregnant women with normal weight and overweight. In other cases, the differences between study groups in fundal height were statistically significant.Conclusions: Body mass index is a variable that affects the character of fundal height curve. To enable high-quality antenatal carem we need to use the curves tailored to anthropometric indicators.Keywords: Body mass index -intrauterine growth restriction -fundal height. Зерттеу 2014 жылдың қантар айынан желтоқсан айы бойы Семей қаласы және аймағында жүргізілді. Салмағы 2500-ден 4000 грамға дейінгі ұрығы жетілген, жүктілік мерзімі асқынусыз өткен 2387 жағдай есепке алынды. Дене салмағы индексіне байланысты жағдайлар үш топқа бөлінді. Бірінші топқа дене салмағы индексі 18,5 төмен жүкті әйелдер кірді. Екінші топқа дене салмағы индексі 18,5-24,9 болатын жүктілер кірді. Үшінші топқа 24-тен жоғары, яғни артық салмақты және семіздікке бой алған жүктілер кірді.

Aim of research: To determine the frequency and degree of decrease in bone mineral density in women of reproductive age who are descendants of persons exposed to radiation as a result of nuclear tests at the Semipalatinsk test site. The study included 383 women, descendants of non-irradiated and irradiated II and III generations in the female line. The parameters of bone mineral density in 2 age groups (II generation - 1962-1987 year of birth and III generation – 1988-1996 year of birth) were studied by ultrasound densitometry. It was revealed that women of reproductive age with irradiated ancestors of the second and third generation, who lived in areas of maximum and extreme radiation risk, had a relative decrease in bone mineral density, which was statistically significant in relation to the descendants of persons who were not exposed to chronic anthropogenic sources of ionizing radiation. There were statistically significant relationship between exposure ancestors II and III generation and indicators BMD their offspring, women of reproductive age. It is possible to predict the rapid development of involutional osteoporosis in women-descendants of irradiated patients in the ІІ and ІІІ generation.

IntroductionReproductive health is characterized by the condition of the woman in association with the course of pregnancy and childbirth. In this case, the absence of disease plays a fundamental role. Unfortunately, conditions that can negatively impact reproductive health and cause deterioration of pregnancy and delivery outcomes are frequent in women of reproductive age. Antiphospholipid syndrome (APS) is one of the leading conditions that can negatively affect reproductive health and lead to various complications in pregnancy including fetal loss.Materials and methodsWe assessed the effectiveness of pre-conception preparing, including traditional therapy of APS in conjunction with system enzyme therapy (SET) and plasmapheresis sessions. We conducted a study in two groups: women with APS and pre-conception preparing (n = 49) and the control group were women without pre-conception preparing (n = 46).ResultsThe effect of pre-conception preparing in women with APS was assessed by the course and outcome of pregnancy. The total number of women with complications of pregnancy were 39.1% lower in the study group compared to the control group. Risk of miscarriage in the basic group observed 68.7 % less frequently compared to the control group. The frequency of pre-eclampsia was 63.5 % less in the study group compared to the control group. We observed significantly lower rates of placental insufficiency in the study group and the difference in this parameter reached 65.2%. The risk of pre-term birth was 59.4 % lower in the study group compared to the control group.ConclusionWe concluded that pre-conception preparing in women with APS increases the possibility of physiological course pregnancy. Pre-conception preparing reduces the incidence of miscarriage, pre-term labor, and the development of pre-eclampsia, and placental insufficiency.