High mortality rate and organizational problems in rendering assistance make researchers in many countries pay special attention to implement protocols and conception allowing to improve the early appropriate treating of polytrauma (Early Appropriate Care, EAC)), the strategy of safe operations (Safe Definitive Surgery, SDS), and prompt individual safe treatment (Prompt Individualised Safe Management, PR.I.S.M.). We propose the conception of «metabolic rehabilitation», which enables to significantly reduce the mortality and disability rates and improve the functional outcomes. Despite the recent advances, the problem of accurate diagnostics and minimally invasive treatment remains topical in polytrauma clinic.
Цель работы – улучшить результаты лечения пациентов с дегенеративно-дистрофическими заболеваниями позвоночника с использованием мультимодального подхода в аналгезии. В 2019 г. в отделении нейрохирургии РТЦ г. Донецка по поводу болевого и корешкового синдрома проведено 15 эпидуральных блокад в поясничном отделе позвоночника с дополнительным введением во время процедуры опиоидных препаратов и кетамина. Процедуру проводили в условиях операционной под местной анестезией. Положительный клинический эффект достигнут у большинства пациентов. Требуется модернизация схем комплексного лечения.
В данном сообщении приведены результаты исследования функциональных исходов лечения с использованием оценочной шкалы Харриса 25 больных с переломами задней стенки вертлужной впадины, лечившихся традиционным способом с использованием хирургического доступа Кохера — Лангенбека. Результаты исследования свидетельствуют о неудовлетворительном функциональном исходе лечения, по скольку балльная оценка по группе спустя год после травмы не превышала 69,60, что расценивается как плохой показатель.
Introduction. Techniques that use growth factors to improve bone fragment consolidation and to treat the inflammatory and degenerative diseases of the musculoskeletal system have become very popular. Many researchers are actively searching for personification of this therapy and the reasons for delayed consolidation. The purpose of the study – to identify the biomarker for delayed bone consolidation.Materials and Methods. The study groups consisted of patients with high-energy tibia open fractures with normal (group 1) and with delayed (2nd group) consolidation of bone fragments. The enzymatic activity of platelet-derived growth factor (PDGF) in blood serum was studied after 7 days and in 1, 3 and 6 months after bone fragments reduction. Spectrophotometric technique (Specord-200) was used.Results. In patients with normal consolidation of bone fragments, the enzymatic activity of PDGF was statistically significantly higher in comparison with the group with delayed healing. At the same time, the highest activity was reported on day 7, and by third month it was becoming lower.Conclusion. Bone healing depends on PDGF enzymatic activity, besides significant differences on various stages of healing were observed. Further study the reasons for the PDGF enzymatic deficiency and its correction are of a great interest for reducing the timing of consolidation.
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