The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I—II stages, included detection levels of circulating desquamated endothelial cells, endothelin-1, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S100. Reliable changes of immune status as well as signs of endothelium dysfunction progressed with stage of CBI. Direct correlation between intensity of endothelium dysfunction and activity of neurodegererative process in brain was revealed.

The use of divazа resulted in clinical improvement and normalization of markers of endothelial dysfunction as well.

The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I-II stages (44 males and 62 females). The age of examined patients varied from 38 to 67 years (mean age was 55,6 ± 2,2). The diagnosis of CBI was estimated according to the generally accepted criteria. Results of laboratory investigation of 22 practically healthy people (10 males and 12 females) served as control. The age of control group varied from 35 to 64 years (mean age was 53,2 ± 2,1). Laboratory diagnostics included detection levels of circulating endothelial cells, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S-100. Reliable changes of immune status as well as signs of endothelium dysfunction was revealed. These indices are expressed in patients with CBI II stage. Direct correlation between intensity of endothelium dysfunction and activity of autoimmune aggression in brain was revealed.

242 patients with discirculatory encephalopathy were examined: 120 of them were the liquidators of the Chernobyl nuclear disaster and 122 patients were without radiation anamnesis. We studied the variants of structural changes of the main brain arteries by ultrasonic scanning. We arrived at a conclusion that that liquidators of the Chernobyl APP had an acute form of main brain arteries’ affection. Radiation effect correlates with the significant hemodynamics stenosis of the internal carotid artery (r = 0,5; р < 0,05).

The purpose of work was improvement cognitive functions at patients after an ischemic insult in the early regenerative period by inclusion in a complex of rehabilitation cognitive gymnastics.123 patients in the age of from 45 till 60 years after an insult are surveyed. Sick by a method of casual selection are divided on two groups, at 61 the complex of physical rehabilitation joined regular employment cognitive gymnastics, the others 62 patients received a standard complex of rehabilitation actions. An estimation cognitive functions it was carried out with use of following techniques: the reduced multifactorial questionnaire for research of the person, «Memory for the images», «Memory on numbers», «Tables Shultie», a brief scale of an estimation of the mental status (MMSE), a questionnaire «Quality of a life» SF-36.After a rate of employment cognitive gymnastics have improved cognitive functions: frustration of short-term memory and any attention have considerably decreased, the degree of quality of a life has raised, the mood has improved, the level of asteno-neurotic reactions and leaving in illness has decreased, the self-estimation has raised. The undesirable phenomena at one of patients during the lead treatment it has not been revealed.Employment cognitive gymnastics are effective at patients after an insult in complex sanatorium rehabilitation owing to positive action on cognitive functions, to increase of a degree of quality of a life.