No abstract

Favorable conditions for development, reproduction, and accumulation of large amounts of zoophilous flies in commercial poultry farms are caused by incomplete compliance with veterinary and sanitary rules for growing in cage facilities. The purpose of the study was to test a systematic insecticidal program for destroying flies' populations using adulticide and larvicide drugs in poultry farms under battery cage management. The number of imago flies in hen houses was dynamically evaluated using flypapers, six flypapers in each hen house, situated in different levels above the floor. Flypapers were removed and the number of stuck insects was counted. The number of larvae was evaluated in dynamics by specimen testing from the floor area 10x10 cm, with weight of 3-5 g. The Quick Bayt WG 10% was applied to destroy the imago of flies. Baycidal® WP 25% was used against larvae of flies. Complex insecticide program Quick Bayt WG 10% + Baycidal® WP 25% provided the opportunity to destroy flies, with a significant difference in intensefficacy, (98.3 % for adult flies and 99.8 % for larvae). Furthermore, this program had a positive impact on economic indicators of meat production of broilers. The present study demonstrated high preventive efficacy and economical efficacy of complex program against flies under battery cage broiler management.

No abstract

Всероссийский научно-исследовательский институт фундаментальной и прикладной паразитологии животных и растений -филиал Федерального государственного бюджетного научного учреждения «Федеральный научный центр -Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К. И. Скрябина и Я. Р. Коваленко Российской академии наук»,

Determining the degree of safety of new antiparasitic drugs for veterinary use is based on the results of a whole complex of preclinical study. The quality and effectiveness of preclinical studies are guaranteed by compliance with the rules provided for in normative documents, which are harmonized with international standards. However, due to the exploratory nature of such studies and the variety of methodological approaches used, there are no strict criteria for planning experiments. The choice of methods and tools when planning work on the preclinical evaluation of safety and efficacy of antiparasitic agents should be based on the specifics of their chemical structure and application to the target animals. The paper considers approaches to the regulation of preclinical toxicology studies of antiparasitic agents for veterinary use, taking into account their usually high or medium toxicity, the ability to cause death or impaired functions in living things (both the parasite and the host) and short-term use of the target to animals. The use of such approaches will make it possible to unify the methodology of experiments, to ensure the reliability and reproducibility of the results of preclinical pharmacology studies, and to increase their scientific and practical significance.