The paper presents the results of monitoring of intraschool factors and gives a hygienic assessment of the sanitary and epidemiological wellbeing of schools and the organization of the educational process in schools of Chelyabinsk. It was established that 56.4 % of establishments with satisfactory conditions of stay and education belong to the second group and 0.6 % of schools belong to the third group of sanitary and epidemiological wellbeing. In the study of class schedules, non-compliance with hygienic standards was found in 26.3 % of cases. Subjects of high difficulty level are put the first on schedule in 15.0 % of cases and during 5–8 lessons in 10.0 % of cases. We assessed the anxiety levels of 5–11th grade students (total 2 032 schoolchildren). High levels of reactive anxiety were found among 35.7 % of students and personal anxiety among 37.0 % of schoolchildren respectively. The most significant causes of psychological discomfort in educational establishments are the conditions of a new digital intraschool environment and educational overload, which can manifest themselves in a high anxiety level among students, which necessitates the development of hygienic principles for the formation of a health-saving environment.

The current system of socio-hygienic monitoring provides the solution of the following tasks: priority and systematization of risk factors, assessment and forecast of risk for the health of the children population, planning and control of the activities of supervisory authorities with the introduction of a risk-based approach into their practice. Therefore, there was a need to summarize the huge and insufficiently systematic material of many-years research to assess the risk fir the health of the children population. The paper summarizes the materials of the annual “State Reports on the Sanitary and Epidemiological Well-Being of the Population of the Chelyabinsk Region” over the past three years. There is given an assessment of the risk forecast, including an assessment of the risk to the health of the children population, statistical methods for analyzing and assessing the structure of diseases under the influence of environmental factors, social factors and a risk-based approach to control and surveillance activities to assess the sanitary and epidemiological situation at educational facilities. There are identified main priority sanitary and epidemiological, social risk factors that form negative trends in the health status of the region’s children, with an analysis of the structure of their incidence, an assessment of the risk of multi-environmental exposure to chemical environmental factors. The causal relationship between the morbidity structure in children and adolescents with the negative influence of environmental factors and their lifestyle has been revealed. The on-alertness for the health of the child population living in three territories of the region is noted to be in the range of acceptable risk. The analysis of carcinogenic risk revealed the main risk factors for the population when consuming water and agricultural products to include the presence of arsenic and chloroform in them. In 2018, 0.05% of children’s organizations were established to be assigned to the high-risk group, 6.5% - to the significant-risk group, and 1.9% - to the low-risk group. The implemented risk-based approach to the practice of control and supervision activities of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare and systematic long-term monitoring of data made it possible to improve the sanitary and epidemiological situation at the objects of education and training of children and adolescents.

Represents the results of a clinical trial implantation xenopericardial prosthesis mounted on a frame of variable stiffness "Tiara" in the aortic position. Prosthesis implanted in a single-row suture cubcoronary supraannulary position. Implantation performed two patients 71 and 75 years with a good clinical outcome. According to the control echocardiography peak gradients at rest were 9-15 mm Hg. According to the results of a clinical trial prosthesis can be recommended for implementation in everyday clinical practice.

В монографии рассматриваются актуальные вопросы, стоящие перед современными исследователями, предлагаются оригинальные решения ряда научно-методических и технологических вопросов. Издание может быть полезно научным работникам, специалистампрактикам, преподавателям всех уровней образования, интересующимся проблемами развития современной науки и технологий.Авторы публикуемых материалов несут ответственность за содержание своих работ, точность цитат, легитимность использования иллюстраций, приведенных цифр, фактов, названий, персональных данных и иной информации, а также за соблюдение законодательства Российской Федерации и сам факт публикации.Полные тексты всех глав в открытом доступе размещены в Научной электронной библиотеке Elibrary.ru в соответствии с Договором № 467-03/2018K от 19.03.2018 г.УДК 001.12 ББК 70