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The study is aimed at studying the indices of the digestibility of nutrients in broiler chickens' diet and morphohistological changes in the duodenum and pancreas with additional administration and when replacing the feed antibiotic in the feed for a complex preparation, including phytoextracts, essential oils and protected organic acids. The study is based on the methods of industrial testing of the effectiveness of feed and commercial products in accordance with the methods of the Federal Research Center "VNITIP" RAS (2013). For calculations, the method of variation statistics is used with the use of the PC “Microsoft Excel”. The assessment of the statistical significance of differences between groups was carried out using the Student's t-test. Results. It was found that the tested feed additive, which includes essential oils, protected organic acids, and hot pepper extract, promoted an increase in the digestion of fiber and fat by broiler chickens. The morphohistological study has shown that the processes of food digestion during the active work of the pancreas create conditions for the normal life of the bird without the manifestation of pathological processes. Scientific novelty of the work. Recently, the use of antibiotic drugs has been widely discussed in scientific circles and in the general press, shaping public opinion. There has been a significant increase in the number of publications dealing with the use of alternative antibiotics additives that promote the growth of poultry, enhance the immune response. Under these conditions, for the first time in a comparative study, the reserves of increasing the productive qualities of poultry were substantiated due to the use in the composition of compound feed in addition and instead of feed antibiotics additives, including phytoextracts, essential oils and protected organic acids. Namely, new data were obtained on the influence of the studied feed factor on the digestibility and use of nutrients of feed, the morphohistological state of the duodenum and pancreas.

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This article highlights current issues on medical treatment of chronic periodontitis. The lack of effective comprehensive approach to treatment of chronic periodontitis requires to seek for new treatment strategies, which will be based on pathogenetic features of disease development. Experimental study with Wistar rat strain was used as a model of chronic periodontitis created by inserting a 12 mm needle into the periodontal space of the lower incisor. More than 30 models of chronic periodontitis were obtained. A method of conservative therapy by using an immunomodulator (polyoxidonium) was proposed. The aim of the study was to evaluate efficacy of polyoxidonium in treatment of chronic periodontitis model. To do this, we compared efficacy of treatment with polyoxidonium and treatment with an antibacterial drug, Metrogil Denta gel. Development of model of chronic periodontitis was performed in two groups of our study. In the first group, periodontitis was treated with polyoxidonium injected into alveolar process mucosa of the lower jaw. In the second group – antibacterial gel “Metrogil Denta” was applied to the area of inflammation. Finally, clinical and histological assessment of therapeutic efficacy was performed. It was found that the main clinical parameters after immunomodulatory therapy were not inferior to those obtained after treatment with Metrogil Denta gel. During treatment, hyperemia, edema, and bleeding gums were decreased in both groups. Evaluation of clinical data after treatment with polyoxidonium suggested that improved parameters evidenced about good immune-mediated activity of the drug and need to continue further efficacy examination in treatment of inflammatory periodontal diseases. To assess the histological picture, 60 decalcified sections were examined (two per each animal, respectively). Data from control group without treatment were described previously, and were used for comparison. Histological examination confirmed ongoing healing process in all three groups. In group 1 treated with immunomodulator, pharmacological properties of polyoxidonium favorably affected regeneration of periodontal tissue, which, however, required longer period of time, more than 20 days. It proves a pronounced efficacy of polyoxidonium in treatment of inflammatory periodontal diseases, even as a standalone therapy without combining with antibacterial drugs.